TY - JOUR TI - Leader β-cells coordinate Ca 2+ dynamics across pancreatic islets in vivo AU - Salem, Victoria AU - Silva, Luis Delgadillo AU - Suba, Kinga AU - Georgiadou, Eleni AU - Gharavy, S. Neda Mousavy AU - Akhtar, Nadeem AU - Martin-Alonso, Aldara AU - Gaboriau, David C. A. AU - Rothery, Stephen M. AU - Stylianides, Theodoros AU - Carrat, Gaelle AU - Pullen, Timothy J. AU - Singh, Sumeet Pal AU - Hodson, David J. AU - Leclerc, Isabelle AU - Shapiro, A. M. James AU - Marchetti, Piero AU - Briant, Linford J. B. AU - Distaso, Walter AU - Ninov, Nikolay AU - Rutter, Guy A. T2 - Nature Metabolism AB - Pancreatic β-cells are highly connected, and this network is crucial for the pulsatile release of insulin. Here Salem and colleagues demonstrated the existence of leader β-cells that respond first to glucose and are more closely linked to the other β-cells. They also showed that glucose increases β-cell calcium dynamics and connectivity between the leader and non-leader β-cells. DA - 2019/06// PY - 2019 DO - 10.1038/s42255-019-0075-2 DP - www.nature.com VL - 1 IS - 6 SP - 615 LA - En SN - 2522-5812 UR - https://www.nature.com/articles/s42255-019-0075-2 AN - https://kclpure.kcl.ac.uk/portal/en/publications/leader-cells-coordinate-ca2-dynamics-across-pancreatic-islets-in-vivo(db850d42-a608-4d96-913e-b60a94461d75).html DB - King's Research Portal Y2 - 2019/06/28/08:38:40 KW - WP4 KW - WP5 ER -