%0 Journal Article %T Leader β-cells coordinate Ca 2+ dynamics across pancreatic islets in vivo %V 1 %N 6 %P 615 %W https://kclpure.kcl.ac.uk/portal/en/publications/leader-cells-coordinate-ca2-dynamics-across-pancreatic-islets-in-vivo(db850d42-a608-4d96-913e-b60a94461d75).html %* 2019 The Author(s), under exclusive licence to Springer Nature Limited %U https://www.nature.com/articles/s42255-019-0075-2 %X Pancreatic β-cells are highly connected, and this network is crucial for the pulsatile release of insulin. Here Salem and colleagues demonstrated the existence of leader β-cells that respond first to glucose and are more closely linked to the other β-cells. They also showed that glucose increases β-cell calcium dynamics and connectivity between the leader and non-leader β-cells. %G En %J Nature Metabolism %A Salem, Victoria %A Silva, Luis Delgadillo %A Suba, Kinga %A Georgiadou, Eleni %A Gharavy, S. Neda Mousavy %A Akhtar, Nadeem %A Martin-Alonso, Aldara %A Gaboriau, David C. A. %A Rothery, Stephen M. %A Stylianides, Theodoros %A Carrat, Gaelle %A Pullen, Timothy J. %A Singh, Sumeet Pal %A Hodson, David J. %A Leclerc, Isabelle %A Shapiro, A. M. James %A Marchetti, Piero %A Briant, Linford J. B. %A Distaso, Walter %A Ninov, Nikolay %A Rutter, Guy A. %D 2019/06 %K WP4 WP5