@article{salem_leader_2019, title = {Leader β-cells coordinate Ca 2+ dynamics across pancreatic islets in vivo}, volume = {1}, rights = {2019 The Author(s), under exclusive licence to Springer Nature Limited}, issn = {2522-5812}, url = {https://www.nature.com/articles/s42255-019-0075-2}, doi = {10.1038/s42255-019-0075-2}, abstract = {Pancreatic β-cells are highly connected, and this network is crucial for the pulsatile release of insulin. Here Salem and colleagues demonstrated the existence of leader β-cells that respond first to glucose and are more closely linked to the other β-cells. They also showed that glucose increases β-cell calcium dynamics and connectivity between the leader and non-leader β-cells.}, pages = {615}, number = {6}, journaltitle = {Nature Metabolism}, author = {Salem, Victoria and Silva, Luis Delgadillo and Suba, Kinga and Georgiadou, Eleni and Gharavy, S. Neda Mousavy and Akhtar, Nadeem and Martin-Alonso, Aldara and Gaboriau, David C. A. and Rothery, Stephen M. and Stylianides, Theodoros and Carrat, Gaelle and Pullen, Timothy J. and Singh, Sumeet Pal and Hodson, David J. and Leclerc, Isabelle and Shapiro, A. M. James and Marchetti, Piero and Briant, Linford J. B. and Distaso, Walter and Ninov, Nikolay and Rutter, Guy A.}, urldate = {2019-06-28}, date = {2019-06}, keywords = {{WP}4, {WP}5}, }