Our publications
dsSwissKnife: An R package for federated data analysis.
bioRxiv 2020.11.17.386813 (2020). doi: 10.1101/2020.11.17.386813
Pancreatic Steatosis Associates With Impaired Insulin Secretion in Genetically Predisposed Individuals.
The Journal of Clinical Endocrinology & Metabolism 105, dgaa435 (2020). doi: 10.1210/clinem/dgaa435
Functional Genomics in Pancreatic β Cells: Recent Advances in Gene Deletion and Genome Editing Technologies for Diabetes Research.
Frontiers in Endocrinology 11, 576632 (2020). doi: 10.3389/fendo.2020.576632
Covid-19 and Diabetes: A Complex Bidirectional Relationship.
Frontiers in Endocrinology 11, 582936 (2020). doi: 10.3389/fendo.2020.582936
Transcription factors that shape the mammalian pancreas.
Diabetologia 63, 1974–1980 (2020). doi: 10.1007/s00125-020-05161-0
Benchmarking the Cost-Effectiveness of Interventions Delaying Diabetes: A Simulation Study Based on NAVIGATOR Data.
Diabetes Care 43, 2485–2492 (2020). doi: 10.2337/dc20-0717
The making of insulin in health and disease.
Diabetologia 63, 1981–1989 (2020). doi: 10.1007/s00125-020-05192-7
An investigation of causal relationships between prediabetes and vascular complications.
Nature Communications 11, 4592 (2020). doi: 10.1038/s41467-020-18386-9
Evaluating the Ability of Economic Models of Diabetes to Simulate New Cardiovascular Outcomes Trials: A Report on the Ninth Mount Hood Diabetes Challenge.
Value in Health 23, 1163–1170 (2020). doi: 10.1016/j.jval.2020.04.1832
A surrogate of Roux-en-Y gastric bypass (the enterogastro anastomosis surgery) regulates multiple beta-cell pathways during resolution of diabetes in ob/ob mice.
EBioMedicine 58, 102895 (2020). doi: 10.1016/j.ebiom.2020.102895
The Constitutive Lack of α7 Nicotinic Receptor Leads to Metabolic Disorders in Mouse.
Biomolecules 10, 1057 (2020). doi: 10.3390/biom10071057
Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis.
bioRxiv 2020.05.18.099200 (2020). doi: 10.1101/2020.05.18.099200
Intravital imaging of islet Ca <sup>2+</sup> dynamics reveals enhanced β cell connectivity after bariatric surgery in mice.
(Cell Biology, 2020). http://biorxiv.org/lookup/doi/10.1101/2020.05.05.078725.
Synthesis and in vivo behaviour of an exendin-4-based MRI probe capable of β-cell-dependent contrast enhancement in the pancreas.
Dalton Transactions 49, 4732–4740 (2020). doi: 10.1039/D0DT00332H
Dysfunction of Persisting β Cells Is a Key Feature of Early Type 2 Diabetes Pathogenesis.
Cell Reports 31, 107469 (2020). doi: 10.1016/j.celrep.2020.03.033
Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a new regulator of insulin secretion.
(Cell Biology, 2020). http://biorxiv.org/lookup/doi/10.1101/2020.03.31.017707.
Understanding functional consequences of type 2 diabetes risk loci using the universal data integration and visualization R package CONQUER.
(Genomics, 2020). http://biorxiv.org/lookup/doi/10.1101/2020.03.27.011627.
The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis.
bioRxiv 2020.03.25.007286 (2020). doi: 10.1101/2020.03.25.007286
The influence of peptide context on signalling and trafficking of glucagon-like peptide-1 receptor biased agonists.
bioRxiv 2020.02.24.961524 (2020). doi: 10.1101/2020.02.24.961524
Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization.
bioRxiv 2020.01.27.921643 (2020). doi: 10.1101/2020.01.27.921643
Klf6 protects β-cells against insulin resistance-induced dedifferentiation.
Molecular Metabolism (2020). doi: 10.1016/j.molmet.2020.02.001
Control by Ca2+ of mitochondrial structure and function in pancreatic β-cells.
Cell Calcium 91, 102282 (2020). doi: 10.1016/j.ceca.2020.102282
The pore-forming subunit MCU of the mitochondrial Ca2+ uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice.
Diabetologia 63, 1368–1381 (2020). doi: 10.1007/s00125-020-05148-x
Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity.
Diabetologia 63, 395–409 (2020). doi: 10.1007/s00125-019-05046-x
The supply chain of human pancreatic β cell lines.
The Journal of Clinical Investigation 129, 3511–3520 (2019). doi: 10.1172/JCI129484
Metabolically phenotyped pancreatectomized patients as living donors for the study of islets in health and diabetes.
Molecular Metabolism 27, S1-S6 (2019). doi: 10.1016/j.molmet.2019.06.006
Use of preclinical models to identify markers of type 2 diabetes susceptibility and novel regulators of insulin secretion – A step towards precision medicine.
Molecular Metabolism 27, S147-S154 (2019). doi: 10.1016/j.molmet.2019.06.008
NACHO: an R package for quality control of NanoString nCounter data.
Bioinformatics btz647 (2019). doi: 10.1093/bioinformatics/btz647
Fostering improved human islet research: a European perspective.
Diabetologia 62, 1514–1516 (2019). doi: 10.1007/s00125-019-4911-4
Leader β-cells coordinate Ca 2+ dynamics across pancreatic islets in vivo.
Nature Metabolism 1, 615 (2019). doi: 10.1038/s42255-019-0075-2
The tRNA Epitranscriptome and Diabetes: Emergence of tRNA Hypomodifications as a Cause of Pancreatic β-Cell Failure.
Endocrinology 160, 1262–1274 (2019). doi: 10.1210/en.2019-00098
Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes.
Molecular Metabolism (2019). doi: 10.1016/j.molmet.2019.03.004
ICA512 RESP18 homology domain is a protein condensing factor and insulin fibrillation inhibitor.
bioRxiv 521351 (2019). doi: 10.1101/521351
Decision models of prediabetes populations: A systematic review.
Diabetes, Obesity and Metabolism 21, 1558–1569 (2019). doi: 10.1111/dom.13684
The Expression of Aldolase B in Islets Is Negatively Associated With Insulin Secretion in Humans.
The Journal of Clinical Endocrinology & Metabolism 103, 4373–4383 (2018). doi: 10.1210/jc.2018-00791
Inflammatory stress in islet β-cells: therapeutic implications for type 2 diabetes?.
Current Opinion in Pharmacology 43, 40–45 (2018). doi: 10.1016/j.coph.2018.08.002
Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes.
Nucleic Acids Research 46, 10302–10318 (2018). doi: 10.1093/nar/gky839
Prediction of Glucose Tolerance without an Oral Glucose Tolerance Test.
Frontiers in Endocrinology 9, (2018). doi: 10.3389/fendo.2018.00082
Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables.
The Lancet Diabetes & Endocrinology 6, 361–369 (2018). doi: 10.1016/S2213-8587(18)30051-2
Modeling human pancreatic beta cell dedifferentiation.
Molecular Metabolism 10, 74–86 (2018). doi: 10.1016/j.molmet.2018.02.002
Manipulation and Measurement of AMPK Activity in Pancreatic Islets.
in AMPK (Neumann, D. & Viollet, B.eds. ) 1732, 413–431 (Springer New York, 2018). http://link.springer.com/10.1007/978-1-4939-7598-3_26.
MondoA Is an Essential Glucose-Responsive Transcription Factor in Human Pancreatic β-Cells.
Diabetes 67, 461–472 (2018). doi: 10.2337/db17-0595
HbA1c is associated with altered expression in blood of cell cycle- and immune response-related genes.
Diabetologia 61, 138–146 (2018). doi: 10.1007/s00125-017-4467-0
Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells.
Molecular Metabolism 6, 1024–1039 (2017). doi: 10.1016/j.molmet.2017.06.001
Lifestyle and precision diabetes medicine: will genomics help optimise the prediction, prevention and treatment of type 2 diabetes through lifestyle therapy?.
Diabetologia 60, 784–792 (2017). doi: 10.1007/s00125-017-4207-5
Computer simulation models of pre-diabetes populations: a systematic review protocol.
BMJ Open 7, e014954 (2017). doi: 10.1136/bmjopen-2016-014954
Painting a new picture of personalised medicine for diabetes.
Diabetologia 60, 793–799 (2017). doi: 10.1007/s00125-017-4210-x
Lifestyle precision medicine: the next generation in type 2 diabetes prevention?.
BMC Medicine 15, (2017). doi: 10.1186/s12916-017-0938-x
Local and regional control of calcium dynamics in the pancreatic islet.
Diabetes, Obesity and Metabolism 19, 30–41 (2017). doi: 10.1111/dom.12990
Phospholipase A2 as a probe of phospholipid distribution in erythrocyte membranes. Factors influencing the apparent specificity of the reaction.
Biochemistry 14, 5400–5408 (1975). doi: 10.1021/bi00696a003
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This project receives funding from the Innovative Medicines Initiative 2 Joint Undertaking (www.imi.europa.eu) under grant agreement No 115881. This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation programme and EFPIA.

This work is supported by the Swiss State Secretariat for Education‚ Research and Innovation (SERI) under contract number 16.0097-2.

The opinions expressed and arguments employed herein do not necessarily reflect the official views of these funding bodies.