RHAPSODY Project

Members section

Federated Database

Clustering & biomarkers

Organ dysfunction

Regulatory & economics

Our publications

Cruciani-Guglielmacci, C., Meneyrol, K., Denom, J., Kassis, N., Rachdi, L., Makaci, F., Migrenne-Li, S., Daubigney, F., Georgiadou, E., Denis, R. G., Rodriguez Sanchez-Archidona, A., Paul, J.-L., Thorens, B., Rutter, G. A., Magnan, C., Le Stunff, H. & Janel, N.

Homocysteine Metabolism Pathway Is Involved in the Control of Glucose Homeostasis: A Cystathionine Beta Synthase Deficiency Study in Mouse.

Cells 11, 1737 (2022). doi: 10.3390/cells11111737. Archive: PMC

Emamipour, S., Pagano, E., Di Cuonzo, D., Konings, S. R. A., van der Heijden, A. A., Elders, P., Beulens, J. W. J., Leal, J. & Feenstra, T. L.

The transferability and validity of a population-level simulation model for the economic evaluation of interventions in diabetes: the MICADO model.

Acta Diabetologica (2022). doi: 10.1007/s00592-022-01891-2. Archive: WARP

Hempel, S., Oehme, F., Ehehalt, F., Solimena, M., Kolbinger, F., Bogner, A., Welsch, T., Weitz, J. & Distler, M.

The Impact of Pancreatic Head Resection on Blood Glucose Homeostasis in Patients with Chronic Pancreatitis.

Journal of Clinical Medicine 11, 663 (2022). doi: 10.3390/jcm11030663. Archive: PMC

Jones, B., Burade, V., Akalestou, E., Manchanda, Y., Ramchunder, Z., Carrat, G., Nguyen‐Tu, M., Marchetti, P., Piemonti, L., Leclerc, I., Thennati, R., Vilsboll, T., Thorens, B., Tomas, A. & Rutter, G. A.

In vivo and in vitro characterization of GL0034, a novel long-acting glucagon-like peptide-1 receptor agonist.

Diabetes, Obesity and Metabolism 24, 2090–2101 (2022). doi: 10.1111/dom.14794. Archive: PMC

Leal, J., Becker, F., Feenstra, T., Pagano, E., Jensen, T. M., Vistisen, D., Witte, D. R. & Jorgensen, M. E.

Health‐related quality of life for normal glycaemia, prediabetes and type 2 diabetes mellitus: Cross‐sectional analysis of the ADDITION‐PRO study.

Diabetic Medicine 39, (2022). doi: 10.1111/dme.14825. Archive: WARP

Raverdy, V., Cohen, R. V., Caiazzo, R., Verkindt, H., Petry, T. B. Z., Marciniak, C., Legendre, B., Bauvin, P., Chatelain, E., Duhamel, A., Drumez, E., Oukhouya-Daoud, N., Chetboun, M., Baud, G., Ahlqvist, E., Wierup, N., Asplund, O., Laferrère, B., Groop, L. & Pattou, F.

Data-driven subgroups of type 2 diabetes, metabolic response, and renal risk profile after bariatric surgery: a retrospective cohort study.

The Lancet Diabetes & Endocrinology 10, 167–176 (2022). doi: 10.1016/S2213-8587(22)00005-5. Archive: HAL

Kemter, E., Müller, A., Neukam, M., Ivanova, A., Klymiuk, N., Renner, S., Yang, K., Broichhagen, J., Kurome, M., Zakhartchenko, V., Kessler, B., Knoch, K.-P., Bickle, M., Ludwig, B., Johnsson, K., Lickert, H., Kurth, T., Wolf, E. & Solimena, M.

Sequential in vivo labeling of insulin secretory granule pools in INS - SNAP transgenic pigs.

Proceedings of the National Academy of Sciences 118, e2107665118 (2021). doi: 10.1073/pnas.2107665118

Slieker, R. C., Donnelly, L. A., Fitipaldi, H., Bouland, G. A., Giordano, G. N., Åkerlund, M., Gerl, M. J., Ahlqvist, E., Ali, A., Dragan, I., Elders, P., Festa, A., Hansen, M. K., van der Heijden, A. A., Aly, D. M., Kim, M., Kuznetsov, D., Mehl, F., Klose, C., Simons, K., Pavo, I., Pullen, T. J., Suvitaival, T., Wretlind, A., Rossing, P., Lyssenko, V., Quigley, C. L., Groop, L., Thorens, B., Franks, P. W., Ibberson, M., Rutter, G. A., Beulens, J. W., ‘t Hart, L. M. & Pearson, E. R.

Distinct Molecular Signatures of Clinical Clusters in People with Type 2 Diabetes: an IMIRHAPSODY Study.

Diabetes db201281 (2021). doi: 10.2337/db20-1281

Akalestou, E., Miras, A. D., Rutter, G. A. & le Roux, C. W.

Mechanisms of Weight Loss After Obesity Surgery.

Endocrine Reviews bnab022 (2021). doi: 10.1210/endrev/bnab022. Archive: Spiral - Imperial College Digital Repository

10.

So, W. Y., Liu, W. N., Teo, A. K. K., Rutter, G. A. & Han, W.

Paired box 6 programs essential exocytotic genes in the regulation of glucose-stimulated insulin secretion and glucose homeostasis.

Science Translational Medicine 13, eabb1038 (2021). doi: 10.1126/scitranslmed.abb1038. Archive: Spiral - Imperial College Digital Repository

11.

Slieker, R. C., Donnelly, L. A., Fitipaldi, H., Bouland, G. A., Giordano, G. N., Åkerlund, M., Gerl, M. J., Ahlqvist, E., Ali, A., Dragan, I., Festa, A., Hansen, M. K., Mansour Aly, D., Kim, M., Kuznetsov, D., Mehl, F., Klose, C., Simons, K., Pavo, I., Pullen, T. J., Suvitaival, T., Wretlind, A., Rossing, P., Lyssenko, V., Legido-Quigley, C., Groop, L., Thorens, B., Franks, P. W., Ibberson, M., Rutter, G. A., Beulens, J. W. J., ‘t Hart, L. M. & Pearson, E. R.

Replication and cross-validation of type 2 diabetes subtypes based on clinical variables: an IMI-RHAPSODY study.

Diabetologia (2021). doi: 10.1007/s00125-021-05490-8

12.

Slieker, R. C., Donnelly, L. A., Lopez-Noriega, L., Muniangi-Muhitu, H., Akalestou, E., Sheikh, M., Georgiadou, E., Giordano, G. N., Åkerlund, M., Ahlqvist, E., Ali, A., Barovic, M., Bouland, G. A., Burdet, F., Canouil, M., Dragan, I., Elders, P. J., Fernandez, C., Festa, A., Fitipaldi, H., Froguel, P., Gudmundsdottir, V., Gudnason, V., Gerl, M. J., van der Heijden, A. A., Jennings, L. L., Hansen, M. K., Kim, M., Leclerc, I., Klose, C., Kuznetsov, D., Aly, D. M., Mehl, F., Marek, D., Melander, O., Niknejad, A., Ottosson, F., Pavo, I., Efanov, A., Duffin, K., Pullen, T. J., Simons, K., Solimena, M., Suvitaival, T., Wretlind, A., Rossing, P., Lyssenko, V., Quigley, C. L., Groop, L., Thorens, B., Franks, P. W., Ibberson, M., Beulens, J. W., ’t Hart, L. M., Pearson, E. R. & Rutter, G. A.

Novel biomarkers for glycaemic deterioration in type 2 diabetes: an IMI RHAPSODY study.

(Endocrinology (including Diabetes Mellitus and Metabolic Disease), 2021). http://medrxiv.org/lookup/doi/10.1101/2021.04.22.21255625.

13.

Shrestha, N., De Franco, E., Arvan, P. & Cnop, M.

Pathological β-Cell Endoplasmic Reticulum Stress in Type 2 Diabetes: Current Evidence.

Frontiers in Endocrinology 12, 650158 (2021). doi: 10.3389/fendo.2021.650158

14.

Ghiasi, S. M. & Rutter, G. A.

Consequences for Pancreatic β-Cell Identity and Function of Unregulated Transcript Processing.

Frontiers in Endocrinology 12, 625235 (2021). doi: 10.3389/fendo.2021.625235

15.

López–Noriega, L. & Rutter, G. A.

Long Non-Coding RNAs as Key Modulators of Pancreatic β-Cell Mass and Function.

Frontiers in Endocrinology 11, 610213 (2021). doi: 10.3389/fendo.2020.610213

16.

Müller, A., Schmidt, D., Xu, C. S., Pang, S., D’Costa, J. V., Kretschmar, S., Münster, C., Kurth, T., Jug, F., Weigert, M., Hess, H. F. & Solimena, M.

3D FIB-SEM reconstruction of microtubule–organelle interaction in whole primary mouse β cells.

Journal of Cell Biology 220, e202010039 (2021). doi: 10.1083/jcb.202010039

17.

Nguyen-Tu, M.-S., Martinez-Sanchez, A., Leclerc, I., Rutter, G. A. & da Silva Xavier, G.

Adipocyte-specific deletion of Tcf7l2 induces dysregulated lipid metabolism and impairs glucose tolerance in mice.

Diabetologia 64, 129–141 (2021). doi: 10.1007/s00125-020-05292-4

18.

Akalestou, E., Suba, K., Lopez-Noriega, L., Georgiadou, E., Chabosseau, P., Gallie, A., Wretlind, A., Legido-Quigley, C., Leclerc, I., Salem, V. & Rutter, G. A.

Intravital imaging of islet Ca2+ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice.

Nature Communications 12, 5165 (2021). doi: 10.1038/s41467-021-25423-8

19.

Hu, M., Cebola, I., Carrat, G., Jiang, S., Nawaz, S., Khamis, A., Canouil, M., Froguel, P., Schulte, A., Solimena, M., Ibberson, M., Marchetti, P., Cardenas-Diaz, F. L., Gadue, P. J., Hastoy, B., Almeida-Souza, L., McMahon, H. & Rutter, G. A.

Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a regulator of insulin secretion.

Cell Reports 34, 108703 (2021). doi: 10.1016/j.celrep.2021.108703

20.

Leal, J., Alva, M., Gregory, V., Hayes, A., Mihaylova, B., Gray, A. M., Holman, R. R. & Clarke, P.

Estimating risk factor progression equations for the UKPDS Outcomes Model 2 (UKPDS 90).

Diabetic Medicine 38, (2021). doi: 10.1111/dme.14656

21.

Mousavy Gharavy, S. N., Owen, B. M., Millership, S. J., Chabosseau, P., Pizza, G., Martinez-Sanchez, A., Tasoez, E., Georgiadou, E., Hu, M., Fine, N. H. F., Jacobson, D. A., Dickerson, M. T., Idevall-Hagren, O., Montoya, A., Kramer, H., Mehta, Z., Withers, D. J., Ninov, N., Gadue, P. J., Cardenas-Diaz, F. L., Cruciani-Guglielmacci, C., Magnan, C., Ibberson, M., Leclerc, I., Voz, M. & Rutter, G. A.

Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis.

Diabetologia 64, 850–864 (2021). doi: 10.1007/s00125-020-05350-x

22.

Pagano, E., Konings, S. R. A., Cuonzo, D. D., Rosato, R., Bruno, G., Heijden, A. A. van der, Beulens, J., Slieker, R., Leal, J. & Feenstra, T. L.

Prediction of mortality and major cardiovascular complications in type 2 diabetes: External validation of UK Prospective Diabetes Study outcomes model version 2 in two European observational cohorts.

Diabetes, Obesity and Metabolism 23, 1084–1091 (2021). doi: 10.1111/dom.14311

23.

Sánchez-Archidona, A. R., Cruciani-Guglielmacci, C., Roujeau, C., Wigger, L., Lallement, J., Denom, J., Barovic, M., Kassis, N., Mehl, F., Weitz, J., Distler, M., Klose, C., Simons, K., Ibberson, M., Solimena, M., Magnan, C. & Thorens, B.

Plasma triacylglycerols are biomarkers of ß-cell function in mice and humans.

Molecular Metabolism 101355 (2021). doi: 10.1016/j.molmet.2021.101355

24.

Thorens, B. & Labouèbe, G.

Détection cérébrale du glucose et homéostasie du glucose.

Médecine des Maladies Métaboliques 15, 518–525 (2021). doi: 10.1016/j.mmm.2021.05.004

25.

Wigger, L., Barovic, M., Brunner, A.-D., Marzetta, F., Schöniger, E., Mehl, F., Kipke, N., Friedland, D., Burdet, F., Kessler, C., Lesche, M., Thorens, B., Bonifacio, E., Legido-Quigley, C., Barbier Saint Hilaire, P., Delerive, P., Dahl, A., Klose, C., Gerl, M. J., Simons, K., Aust, D., Weitz, J., Distler, M., Schulte, A. M., Mann, M., Ibberson, M. & Solimena, M.

Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetes.

Nature Metabolism 3, 1017–1031 (2021). doi: 10.1038/s42255-021-00420-9. Archive: BiorXiv

26.

Wu, C., Borné, Y., Gao, R., López Rodriguez, M., Roell, W. C., Wilson, J. M., Regmi, A., Luan, C., Aly, D. M., Peter, A., Machann, J., Staiger, H., Fritsche, A., Birkenfeld, A. L., Tao, R., Wagner, R., Canouil, M., Hong, M.-G., Schwenk, J. M., Ahlqvist, E., Kaikkonen, M. U., Nilsson, P., Shore, A. C., Khan, F., Natali, A., Melander, O., Orho-Melander, M., Nilsson, J., Häring, H.-U., Renström, E., Wollheim, C. B., Engström, G., Weng, J., Pearson, E. R., Franks, P. W., White, M. F., Duffin, K. L., Vaag, A. A., Laakso, M., Stefan, N., Groop, L. & De Marinis, Y.

Elevated circulating follistatin associates with an increased risk of type 2 diabetes.

Nature Communications 12, 6486 (2021). doi: 10.1038/s41467-021-26536-w

27.

Zakaria, A., Berthault, C., Cosson, B., Jung, V., Guerrera, I. C., Rachdi, L. & Scharfmann, R.

Glucose treatment of human pancreatic β-cells enhances translation of mRNAs involved in energetics and insulin secretion.

Journal of Biological Chemistry 297, 100839 (2021). doi: 10.1016/j.jbc.2021.100839

28.

Bosi, E., Marselli, L., De Luca, C., Suleiman, M., Tesi, M., Ibberson, M., Eizirik, D. L., Cnop, M. & Marchetti, P.

Integration of single-cell datasets reveals novel transcriptomic signatures of β-cells in human type 2 diabetes.

NAR genomics and bioinformatics 2, lqaa097 (2020). doi: 10.1093/nargab/lqaa097

29.

Dragan, I., Sparso, T., Kuznetsov, D., Slieker, R. & Ibberson, M.

dsSwissKnife: An R package for federated data analysis.

bioRxiv 2020.11.17.386813 (2020). doi: 10.1101/2020.11.17.386813

30.

Wagner, R., Jaghutriz, B. A., Gerst, F., Barroso Oquendo, M., Machann, J., Schick, F., Löffler, M. W., Nadalin, S., Fend, F., Königsrainer, A., Peter, A., Siegel-Axel, D., Ullrich, S., Häring, H.-U., Fritsche, A. & Heni, M.

Pancreatic Steatosis Associates With Impaired Insulin Secretion in Genetically Predisposed Individuals.

The Journal of Clinical Endocrinology & Metabolism 105, dgaa435 (2020). doi: 10.1210/clinem/dgaa435

31.

Hu, M., Cherkaoui, I., Misra, S. & Rutter, G. A.

Functional Genomics in Pancreatic β Cells: Recent Advances in Gene Deletion and Genome Editing Technologies for Diabetes Research.

Frontiers in Endocrinology 11, 576–632 (2020). doi: 10.3389/fendo.2020.576632

32.

Muniangi-Muhitu, H., Akalestou, E., Salem, V., Misra, S., Oliver, N. S. & Rutter, G. A.

Covid-19 and Diabetes: A Complex Bidirectional Relationship.

Frontiers in Endocrinology 11, 582936 (2020). doi: 10.3389/fendo.2020.582936

33.

Jennings, R. E., Scharfmann, R. & Staels, W.

Transcription factors that shape the mammalian pancreas.

Diabetologia 63, 1974–1980 (2020). doi: 10.1007/s00125-020-05161-0

34.

Leal, J., Reed, S. D., Patel, R., Rivero-Arias, O., Li, Y., Schulman, K. A., Califf, R. M., Holman, R. R. & Gray, A. M.

Benchmarking the Cost-Effectiveness of Interventions Delaying Diabetes: A Simulation Study Based on NAVIGATOR Data.

Diabetes Care 43, 2485–2492 (2020). doi: 10.2337/dc20-0717

35.

Vasiljević, J., Torkko, J. M., Knoch, K.-P. & Solimena, M.

The making of insulin in health and disease.

Diabetologia 63, 1981–1989 (2020). doi: 10.1007/s00125-020-05192-7

36.

Mutie, P. M., Pomares-Millan, H., Atabaki-Pasdar, N., Jordan, N., Adams, R., Daly, N. L., Tajes, J. F., Giordano, G. N. & Franks, P. W.

An investigation of causal relationships between prediabetes and vascular complications.

Nature Communications 11, 4592 (2020). doi: 10.1038/s41467-020-18386-9

37.

Si, L., Willis, M. S., Asseburg, C., Nilsson, A., Tew, M., Clarke, P. M., Lamotte, M., Ramos, M., Shao, H., Shi, L., Zhang, P., McEwan, P., Ye, W., Herman, W. H., Kuo, S., Isaman, D. J., Schramm, W., Sailer, F., Brennan, A., Pollard, D., Smolen, H. J., Leal, J., Gray, A., Patel, R., Feenstra, T. & Palmer, A. J.

Evaluating the Ability of Economic Models of Diabetes to Simulate New Cardiovascular Outcomes Trials: A Report on the Ninth Mount Hood Diabetes Challenge.

Value in Health 23, 1163–1170 (2020). doi: 10.1016/j.jval.2020.04.1832

38.

Amouyal, C., Castel, J., Guay, C., Lacombe, A., Denom, J., Migrenne-Li, S., Rouault, C., Marquet, F., Georgiadou, E., Stylianides, T., Luquet, S., Le Stunff, H., Scharfmann, R., Clément, K., Rutter, G. A., Taboureau, O., Magnan, C., Regazzi, R. & Andreelli, F.

A surrogate of Roux-en-Y gastric bypass (the enterogastro anastomosis surgery) regulates multiple beta-cell pathways during resolution of diabetes in ob/ob mice.

EBioMedicine 58, 102895 (2020). doi: 10.1016/j.ebiom.2020.102895

39.

Gausserès, B., Liu, J., Foppen, E., Tourrel-Cuzin, C., Rodriguez Sanchez-Archidona, A., Delangre, E., Cruciani-Guglielmacci, C., Pons, S., Maskos, U., Thorens, B., Magnan, C., Movassat, J. & Maouche, K.

The Constitutive Lack of α7 Nicotinic Receptor Leads to Metabolic Disorders in Mouse.

Biomolecules 10, 1057 (2020). doi: 10.3390/biom10071057

40.

Lucey, M., Pickford, P., Bitsi, S., Minnion, J., Ungewiss, J., Schoeneberg, K., Rutter, G. A., Bloom, S. R., Tomas, A. & Jones, B.

Disconnect between signalling potency and in vivo efficacy of pharmacokinetically optimised biased glucagon-like peptide-1 receptor agonists.

Molecular Metabolism 37, 100991 (2020). doi: 10.1016/j.molmet.2020.100991

41.

Clough, T. J., Baxan, N., Coakley, E. J., Rivas, C., Zhao, L., Leclerc, I., Martinez-Sanchez, A., Rutter, G. A. & Long, N. J.

Synthesis and in vivo behaviour of an exendin-4-based MRI probe capable of β-cell-dependent contrast enhancement in the pancreas.

Dalton Transactions 49, 4732–4740 (2020). doi: 10.1039/D0DT00332H. Archive: Europe PMC

42.

Cohrs, C. M., Panzer, J. K., Drotar, D. M., Enos, S. J., Kipke, N., Chen, C., Bozsak, R., Schöniger, E., Ehehalt, F., Distler, M., Brennand, A., Bornstein, S. R., Weitz, J., Solimena, M. & Speier, S.

Dysfunction of Persisting β Cells Is a Key Feature of Early Type 2 Diabetes Pathogenesis.

Cell Reports 31, 107469 (2020). doi: 10.1016/j.celrep.2020.03.033

43.

Bouland, G. A., Beulens, J. W., Nap, J., van der Slik, A. R., Zaldumbide, A., Hart, L. M. & Slieker, R. C.

Understanding functional consequences of type 2 diabetes risk loci using the universal data integration and visualization R package CONQUER.

(Genomics, 2020). http://biorxiv.org/lookup/doi/10.1101/2020.03.27.011627.

44.

Fang, Z., Chen, S., Pickford, P., Broichhagen, J., Hodson, D. J., Corrêa, I. R., Kumar, S., Görlitz, F., Dunsby, C., French, P., Rutter, G. A., Tan, T., Bloom, S. R., Tomas, A. & Jones, B.

The influence of peptide context on signalling and trafficking of glucagon-like peptide-1 receptor biased agonists.

bioRxiv 2020.02.24.961524 (2020). doi: 10.1101/2020.02.24.961524

45.

Akalestou, E., Genser, L. & Rutter, G. A.

Glucocorticoid Metabolism in Obesity and Following Weight Loss.

Frontiers in Endocrinology 11, 59 (2020). doi: 10.3389/fendo.2020.00059

46.

Dumayne, C., Tarussio, D., Sanchez-Archidona, A. R., Picard, A., Basco, D., Berney, X. P., Ibberson, M. & Thorens, B.

Klf6 protects β-cells against insulin resistance-induced dedifferentiation.

Molecular Metabolism (2020). doi: 10.1016/j.molmet.2020.02.001

47.

Berthault, C., Staels, W. & Scharfmann, R.

Purification of pancreatic endocrine subsets reveals increased iron metabolism in beta cells.

Molecular Metabolism 42, 101060 (2020). doi: 10.1016/j.molmet.2020.101060

48.

Carrat, G. R., Haythorne, E., Tomas, A., Haataja, L., Müller, A., Arvan, P., Piunti, A., Cheng, K., Huang, M., Pullen, T. J., Georgiadou, E., Stylianides, T., Amirruddin, N. S., Salem, V., Distaso, W., Cakebread, A., Heesom, K. J., Lewis, P. A., Hodson, D. J., Briant, L. J., Fung, A. C., Sessions, R. B., Alpy, F., Kong, A. P., Benke, P. I., Torta, F., Teo, A. K. K., Leclerc, I., Solimena, M., Wigley, D. B. & Rutter, G. A.

The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis.

Molecular Metabolism 40, 101015 (2020). doi: 10.1016/j.molmet.2020.101015

49.

Da Silva Xavier, G. & Rutter, G. A.

Metabolic and Functional Heterogeneity in Pancreatic β Cells.

Journal of Molecular Biology 432, 1395–1406 (2020). doi: 10.1016/j.jmb.2019.08.005. Archive: University of Birmingham Research Portal

50.

Eizirik, D. L., Pasquali, L. & Cnop, M.

Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure.

Nature Reviews Endocrinology 16, 349–362 (2020). doi: 10.1038/s41574-020-0355-7. Archive: DI-fusion

51.

Georgiadou, E. & Rutter, G. A.

Control by Ca2+ of mitochondrial structure and function in pancreatic β-cells.

Cell Calcium 91, 102282 (2020). doi: 10.1016/j.ceca.2020.102282. Archive: Spiral - Imperial College Digital Repository

52.

Georgiadou, E., Haythorne, E., Dickerson, M. T., Lopez-Noriega, L., Pullen, T. J., da Silva Xavier, G., Davis, S. P. X., Martinez-Sanchez, A., Semplici, F., Rizzuto, R., McGinty, J. A., French, P. M., Cane, M. C., Jacobson, D. A., Leclerc, I. & Rutter, G. A.

The pore-forming subunit MCU of the mitochondrial Ca2+ uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice.

Diabetologia 63, 1368–1381 (2020). doi: 10.1007/s00125-020-05148-x

53.

Lytrivi, M., Castell, A.-L., Poitout, V. & Cnop, M.

Recent Insights Into Mechanisms of β-Cell Lipo- and Glucolipotoxicity in Type 2 Diabetes.

Journal of Molecular Biology 432, 1514–1534 (2020). doi: 10.1016/j.jmb.2019.09.016

54.

Lytrivi, M., Ghaddar, K., Lopes, M., Rosengren, V., Piron, A., Yi, X., Johansson, H., Lehtiö, J., Igoillo-Esteve, M., Cunha, D. A., Marselli, L., Marchetti, P., Ortsäter, H., Eizirik, D. L. & Cnop, M.

Combined transcriptome and proteome profiling of the pancreatic β-cell response to palmitate unveils key pathways of β-cell lipotoxicity.

BMC Genomics 21, 590 (2020). doi: 10.1186/s12864-020-07003-0

55.

Marchetti, P., Suleiman, M., De Luca, C., Baronti, W., Bosi, E., Tesi, M. & Marselli, L.

A direct look at the dysfunction and pathology of the β cells in human type 2 diabetes.

Seminars in Cell & Developmental Biology 103, 83–93 (2020). doi: 10.1016/j.semcdb.2020.04.005

56.

Marselli, L., Piron, A., Suleiman, M., Colli, M. L., Yi, X., Khamis, A., Carrat, G. R., Rutter, G. A., Bugliani, M., Giusti, L., Ronci, M., Ibberson, M., Turatsinze, J.-V., Boggi, U., De Simone, P., De Tata, V., Lopes, M., Nasteska, D., De Luca, C., Tesi, M., Bosi, E., Singh, P., Campani, D., Schulte, A. M., Solimena, M., Hecht, P., Rady, B., Bakaj, I., Pocai, A., Norquay, L., Thorens, B., Canouil, M., Froguel, P., Eizirik, D. L., Cnop, M. & Marchetti, P.

Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes.

Cell Reports 33, 108466 (2020). doi: 10.1016/j.celrep.2020.108466

57.

Oshima, M., Pechberty, S., Bellini, L., Göpel, S. O., Campana, M., Rouch, C., Dairou, J., Cosentino, C., Fantuzzi, F., Toivonen, S., Marchetti, P., Magnan, C., Cnop, M., Le Stunff, H. & Scharfmann, R.

Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity.

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This project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking (www.imi.europa.eu) under grant agreement No 115881. This Joint Undertaking has received support from the European Union’s Horizon 2020 research and innovation programme and EFPIA.

This work has been supported by the Swiss State Secretariat for Education‚ Research and Innovation (SERI) under contract number 16.0097-2.

The opinions expressed and arguments employed herein do not necessarily reflect the official views of these funding bodies.

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