Members section

Biomarkers for precision therapy and prevention of type 2 diabetes

Mini-symposium

10 March 2020
Scania University Hospital, Malmö

Assessing risk and progression of pre-diabetes and type 2 diabetes to enable disease modification

The stated goal of RHAPSODY is to define a molecular taxonomy of type 2 diabetes mellitus (T2D) that will support patient segmentation, inform clinical trial design, and the establishment of regulatory paths for the adoption of novel strategies for diabetes prevention and treatment.

Our plans are built upon:

access to large European cohorts with comprehensive genetic analyses, rich longitudinal clinical, biochemical data and samples
detailed multi-omic maps of key T2D-relevant tissues and organs
large expertise in the development and use of novel genetic, epigenetic, biochemical and physiological experimental approaches
the ability to combine existing and novel data sets through effective data federation and use of these datasets in systems biology approaches towards precision medicine;
expertise in regulatory approval, health economics and patient engagement.

These activities will lead to the discovery of novel biomarkers for improved T2D taxonomy, to support development of pharmaceutical activities, and for use in precision medicine to improve health in Europe and worldwide.

Most recent publications

See all publications

1.

Mutie, P. M., Pomares-Millan, H., Atabaki-Pasdar, N., Jordan, N., Adams, R., Daly, N. L., Tajes, J. F., Giordano, G. N. & Franks, P. W.

An investigation of causal relationships between prediabetes and vascular complications.

Nature Communications 11, 4592 (2020). doi:10.1038/s41467-020-18386-9

2.

Amouyal, C., Castel, J., Guay, C., Lacombe, A., Denom, J., Migrenne-Li, S., Rouault, C., Marquet, F., Georgiadou, E., Stylianides, T., Luquet, S., Le Stunff, H., Scharfmann, R., Clément, K., Rutter, G. A., Taboureau, O., Magnan, C., Regazzi, R. & Andreelli, F.

A surrogate of Roux-en-Y gastric bypass (the enterogastro anastomosis surgery) regulates multiple beta-cell pathways during resolution of diabetes in ob/ob mice.

EBioMedicine 58, 102895 (2020). doi:10.1016/j.ebiom.2020.102895

3.

Gausserès, B., Liu, J., Foppen, E., Tourrel-Cuzin, C., Rodriguez Sanchez-Archidona, A., Delangre, E., Cruciani-Guglielmacci, C., Pons, S., Maskos, U., Thorens, B., Magnan, C., Movassat, J. & Maouche, K.

The Constitutive Lack of α7 Nicotinic Receptor Leads to Metabolic Disorders in Mouse.

Biomolecules 10, 1057 (2020). doi:10.3390/biom10071057

4.

Gharavy, S. N. M., Owen, B., Millership, S. J., Chabosseau, P., Pizza, G., Martinez-Sanchez, A., Tasoez, E., Georgiadou, E., Hu, M., Fine, N. H. F., Jacobson, D. A., Dickerson, M., Idevall-Hagren, O., Montoya, A., Kramer, H., Mehta, Z., Withers, D. J., Ninov, N., Gadue, P. J., Cardenas-Diaz, F. L., Cruciani-Guglielmacci, C., Magnan, C., Ibberson, M., Leclerc, I., Voz, M. & Rutter, G. A.

Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis.

bioRxiv 2020.05.18.099200 (2020). doi:10.1101/2020.05.18.099200

5.

Clough, T. J., Baxan, N., Coakley, E. J., Rivas, C., Zhao, L., Leclerc, I., Martinez-Sanchez, A., Rutter, G. A. & Long, N. J.

Synthesis and in vivo behaviour of an exendin-4-based MRI probe capable of β-cell-dependent contrast enhancement in the pancreas.

Dalton Transactions 49, 4732–4740 (2020). doi:10.1039/D0DT00332H

6.

Carrat, G. R., Haythorne, E., Tomas, A., Haataja, L., Mueller, A., Arvan, P., Piunti, A., Cheng, K., Huang, M., Pullen, T., Georgiadou, E., Stylianides, T., Amirruddin, N. S., Salem, V., Distaso, W., Cakebread, A., Heesom, K. J., Lewis, P. A., Hodson, D., Briant, L. J., Fung, A. C. H., Sessions, R. B., Alpy, F., Kong, A. P. S., Benke, P. I., Torta, F., Teo, A. K. K., Leclerc, I., Solimena, M., Wigley, D. B. & Rutter, G. A.

The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis.

bioRxiv 2020.03.25.007286 (2020). doi:10.1101/2020.03.25.007286

7.

Fang, Z., Chen, S., Pickford, P., Broichhagen, J., Hodson, D. J., Corrêa, I. R., Kumar, S., Görlitz, F., Dunsby, C., French, P., Rutter, G. A., Tan, T., Bloom, S. R., Tomas, A. & Jones, B.

The influence of peptide context on signalling and trafficking of glucagon-like peptide-1 receptor biased agonists.

bioRxiv 2020.02.24.961524 (2020). doi:10.1101/2020.02.24.961524

8.

Dominguez-Meijide, A., Vasili, E., König, A., Cima-Omori, M.-S., Leonov, A., Ryazanov, S., Zweckstetter, M., Griesinger, C. & Outeiro, T. F.

Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization.

bioRxiv 2020.01.27.921643 (2020). doi:10.1101/2020.01.27.921643

9.

Dumayne, C., Tarussio, D., Sanchez-Archidona, A. R., Picard, A., Basco, D., Berney, X. P., Ibberson, M. & Thorens, B.

Klf6 protects β-cells against insulin resistance-induced dedifferentiation.

Molecular Metabolism (2020). doi:10.1016/j.molmet.2020.02.001

10.

Georgiadou, E., Haythorne, E., Dickerson, M. T., Lopez-Noriega, L., Pullen, T. J., da Silva Xavier, G., Davis, S. P. X., Martinez-Sanchez, A., Semplici, F., Rizzuto, R., McGinty, J. A., French, P. M., Cane, M. C., Jacobson, D. A., Leclerc, I. & Rutter, G. A.

The pore-forming subunit MCU of the mitochondrial Ca2+ uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice.

Diabetologia 63, 1368–1381 (2020). doi:10.1007/s00125-020-05148-x

11.

Oshima, M., Pechberty, S., Bellini, L., Göpel, S. O., Campana, M., Rouch, C., Dairou, J., Cosentino, C., Fantuzzi, F., Toivonen, S., Marchetti, P., Magnan, C., Cnop, M., Le Stunff, H. & Scharfmann, R.

Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity.

Diabetologia 63, 395–409 (2020). doi:10.1007/s00125-019-05046-x

12.

Scharfmann, R., Staels, W. & Albagli, O.

The supply chain of human pancreatic β cell lines.

The Journal of Clinical Investigation 129, 3511–3520 (2019). doi:10.1172/JCI129484

13.

Thorens, B., Rodriguez, A., Cruciani-Guglielmacci, C., Wigger, L., Ibberson, M. & Magnan, C.

Use of preclinical models to identify markers of type 2 diabetes susceptibility and novel regulators of insulin secretion – A step towards precision medicine.

Molecular Metabolism 27, S147-S154 (2019). doi:10.1016/j.molmet.2019.06.008

14.

Marchetti, P., Schulte, A. M., Marselli, L., Schoniger, E., Bugliani, M., Kramer, W., Overbergh, L., Ullrich, S., Gloyn, A. L., Ibberson, M., Rutter, G., Froguel, P., Groop, L., McCarthy, M. I., Dotta, F., Scharfmann, R., Magnan, C., Eizirik, D. L., Mathieu, C., Cnop, M., Thorens, B. & Solimena, M.

Fostering improved human islet research: a European perspective.

Diabetologia 62, 1514–1516 (2019). doi:10.1007/s00125-019-4911-4

15.

Salem, V., Silva, L. D., Suba, K., Georgiadou, E., Gharavy, S. N. M., Akhtar, N., Martin-Alonso, A., Gaboriau, D. C. A., Rothery, S. M., Stylianides, T., Carrat, G., Pullen, T. J., Singh, S. P., Hodson, D. J., Leclerc, I., Shapiro, A. M. J., Marchetti, P., Briant, L. J. B., Distaso, W., Ninov, N. & Rutter, G. A.

Leader β-cells coordinate Ca 2+ dynamics across pancreatic islets in vivo.

Nature Metabolism 1, 615 (2019). doi:10.1038/s42255-019-0075-2

16.

Khamis, A., Canouil, M., Siddiq, A., Crouch, H., Falchi, M., Bulow, M. von, Ehehalt, F., Marselli, L., Distler, M., Richter, D., Weitz, J., Bokvist, K., Xenarios, I., Thorens, B., Schulte, A. M., Ibberson, M., Bonnefond, A., Marchetti, P., Solimena, M. & Froguel, P.

Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes.

Molecular Metabolism (2019). doi:10.1016/j.molmet.2019.03.004

17.

Toledo, P. L., Torkko, J. M., Müller, A., Wegbrod, C., Sönmez, A., Solimena, M. & Ermácora, M. R.

ICA512 RESP18 homology domain is a protein condensing factor and insulin fibrillation inhibitor.

bioRxiv 521351 (2019). doi:10.1101/521351

18.

Lytrivi, M., Igoillo-Esteve, M. & Cnop, M.

Inflammatory stress in islet β-cells: therapeutic implications for type 2 diabetes?.

Current Opinion in Pharmacology 43, 40–45 (2018). doi:10.1016/j.coph.2018.08.002

19.

Cosentino, C., Toivonen, S., Diaz Villamil, E., Atta, M., Ravanat, J.-L., Demine, S., Schiavo, A., Pachera, N., Deglasse, J.-P., Jonas, J.-C., Balboa, D., Otonkoski, T., Pearson, E. R., Marchetti, P., Eizirik, D. L., Cnop, M. & Igoillo-Esteve, M.

Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes.

Nucleic Acids Research 46, 10302–10318 (2018). doi:10.1093/nar/gky839

20.

Ahlqvist, E., Storm, P., Käräjämäki, A., Martinell, M., Dorkhan, M., Carlsson, A., Vikman, P., Prasad, R. B., Aly, D. M., Almgren, P., Wessman, Y., Shaat, N., Spégel, P., Mulder, H., Lindholm, E., Melander, O., Hansson, O., Malmqvist, U., Lernmark, Åke, Lahti, K., Forsén, T., Tuomi, T., Rosengren, A. H. & Groop, L.

Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables.

The Lancet Diabetes & Endocrinology 6, 361–369 (2018). doi:10.1016/S2213-8587(18)30051-2

21.

Rutter, G. A., Hodson, D. J., Chabosseau, P., Haythorne, E., Pullen, T. J. & Leclerc, I.

Local and regional control of calcium dynamics in the pancreatic islet.

Diabetes, Obesity and Metabolism 19, 30–41 (2017). doi:10.1111/dom.12990

22.

Canouil, M., Bouland, G. A., Bonnefond, A., Froguel, P., ’t Hart, L. M. & Slieker, R. C.

NACHO: an R package for quality control of NanoString nCounter data.

Bioinformatics doi:10.1093/bioinformatics/btz647

23.

Cosentino, C., Cnop, M. & Igoillo-Esteve, M.

The tRNA epitranscriptome and diabetes: emergence of tRNA hypomodifications as a cause of pancreatic β-cell failure.

Endocrinology doi:10.1210/en.2019-00098

24.

Leal, J., Morrow, L. M., Khurshid, W., Pagano, E. & Feenstra, T.

Decision models of prediabetes populations: A systematic review.

Diabetes, Obesity and Metabolism doi:10.1111/dom.13684

25.

Wagner, R., Jaghutriz, B. A., Gerst, F., Barroso Oquendo, M., Machann, J., Schick, F., Löffler, M., Nadalin, S., Fend, F., Königsrainer, A., Peter, A., Siegel-Axel, D., Ullrich, S., Häring, H.-U., Fritsche, A. & Heni, M.

Pancreatic steatosis associates with impaired insulin secretion in genetically predisposed individuals.

The Journal of Clinical Endocrinology & Metabolism doi:10.1210/clinem/dgaa435

1.

Mutie, P. M., Pomares-Millan, H., Atabaki-Pasdar, N., Jordan, N., Adams, R., Daly, N. L., Tajes, J. F., Giordano, G. N. & Franks, P. W.

An investigation of causal relationships between prediabetes and vascular complications.

Nature Communications 11, 4592 (2020). doi:10.1038/s41467-020-18386-9

2.

Amouyal, C., Castel, J., Guay, C., Lacombe, A., Denom, J., Migrenne-Li, S., Rouault, C., Marquet, F., Georgiadou, E., Stylianides, T., Luquet, S., Le Stunff, H., Scharfmann, R., Clément, K., Rutter, G. A., Taboureau, O., Magnan, C., Regazzi, R. & Andreelli, F.

A surrogate of Roux-en-Y gastric bypass (the enterogastro anastomosis surgery) regulates multiple beta-cell pathways during resolution of diabetes in ob/ob mice.

EBioMedicine 58, 102895 (2020). doi:10.1016/j.ebiom.2020.102895

3.

Gausserès, B., Liu, J., Foppen, E., Tourrel-Cuzin, C., Rodriguez Sanchez-Archidona, A., Delangre, E., Cruciani-Guglielmacci, C., Pons, S., Maskos, U., Thorens, B., Magnan, C., Movassat, J. & Maouche, K.

The Constitutive Lack of α7 Nicotinic Receptor Leads to Metabolic Disorders in Mouse.

Biomolecules 10, 1057 (2020). doi:10.3390/biom10071057

4.

Gharavy, S. N. M., Owen, B., Millership, S. J., Chabosseau, P., Pizza, G., Martinez-Sanchez, A., Tasoez, E., Georgiadou, E., Hu, M., Fine, N. H. F., Jacobson, D. A., Dickerson, M., Idevall-Hagren, O., Montoya, A., Kramer, H., Mehta, Z., Withers, D. J., Ninov, N., Gadue, P. J., Cardenas-Diaz, F. L., Cruciani-Guglielmacci, C., Magnan, C., Ibberson, M., Leclerc, I., Voz, M. & Rutter, G. A.

Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis.

bioRxiv 2020.05.18.099200 (2020). doi:10.1101/2020.05.18.099200

5.

Clough, T. J., Baxan, N., Coakley, E. J., Rivas, C., Zhao, L., Leclerc, I., Martinez-Sanchez, A., Rutter, G. A. & Long, N. J.

Synthesis and in vivo behaviour of an exendin-4-based MRI probe capable of β-cell-dependent contrast enhancement in the pancreas.

Dalton Transactions 49, 4732–4740 (2020). doi:10.1039/D0DT00332H

6.

Carrat, G. R., Haythorne, E., Tomas, A., Haataja, L., Mueller, A., Arvan, P., Piunti, A., Cheng, K., Huang, M., Pullen, T., Georgiadou, E., Stylianides, T., Amirruddin, N. S., Salem, V., Distaso, W., Cakebread, A., Heesom, K. J., Lewis, P. A., Hodson, D., Briant, L. J., Fung, A. C. H., Sessions, R. B., Alpy, F., Kong, A. P. S., Benke, P. I., Torta, F., Teo, A. K. K., Leclerc, I., Solimena, M., Wigley, D. B. & Rutter, G. A.

The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis.

bioRxiv 2020.03.25.007286 (2020). doi:10.1101/2020.03.25.007286

7.

Fang, Z., Chen, S., Pickford, P., Broichhagen, J., Hodson, D. J., Corrêa, I. R., Kumar, S., Görlitz, F., Dunsby, C., French, P., Rutter, G. A., Tan, T., Bloom, S. R., Tomas, A. & Jones, B.

The influence of peptide context on signalling and trafficking of glucagon-like peptide-1 receptor biased agonists.

bioRxiv 2020.02.24.961524 (2020). doi:10.1101/2020.02.24.961524

8.

Dominguez-Meijide, A., Vasili, E., König, A., Cima-Omori, M.-S., Leonov, A., Ryazanov, S., Zweckstetter, M., Griesinger, C. & Outeiro, T. F.

Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization.

bioRxiv 2020.01.27.921643 (2020). doi:10.1101/2020.01.27.921643

9.

Dumayne, C., Tarussio, D., Sanchez-Archidona, A. R., Picard, A., Basco, D., Berney, X. P., Ibberson, M. & Thorens, B.

Klf6 protects β-cells against insulin resistance-induced dedifferentiation.

Molecular Metabolism (2020). doi:10.1016/j.molmet.2020.02.001

10.

Georgiadou, E., Haythorne, E., Dickerson, M. T., Lopez-Noriega, L., Pullen, T. J., da Silva Xavier, G., Davis, S. P. X., Martinez-Sanchez, A., Semplici, F., Rizzuto, R., McGinty, J. A., French, P. M., Cane, M. C., Jacobson, D. A., Leclerc, I. & Rutter, G. A.

The pore-forming subunit MCU of the mitochondrial Ca2+ uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice.

Diabetologia 63, 1368–1381 (2020). doi:10.1007/s00125-020-05148-x

11.

Oshima, M., Pechberty, S., Bellini, L., Göpel, S. O., Campana, M., Rouch, C., Dairou, J., Cosentino, C., Fantuzzi, F., Toivonen, S., Marchetti, P., Magnan, C., Cnop, M., Le Stunff, H. & Scharfmann, R.

Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity.

Diabetologia 63, 395–409 (2020). doi:10.1007/s00125-019-05046-x

12.

Scharfmann, R., Staels, W. & Albagli, O.

The supply chain of human pancreatic β cell lines.

The Journal of Clinical Investigation 129, 3511–3520 (2019). doi:10.1172/JCI129484

13.

Thorens, B., Rodriguez, A., Cruciani-Guglielmacci, C., Wigger, L., Ibberson, M. & Magnan, C.

Use of preclinical models to identify markers of type 2 diabetes susceptibility and novel regulators of insulin secretion – A step towards precision medicine.

Molecular Metabolism 27, S147-S154 (2019). doi:10.1016/j.molmet.2019.06.008

14.

Marchetti, P., Schulte, A. M., Marselli, L., Schoniger, E., Bugliani, M., Kramer, W., Overbergh, L., Ullrich, S., Gloyn, A. L., Ibberson, M., Rutter, G., Froguel, P., Groop, L., McCarthy, M. I., Dotta, F., Scharfmann, R., Magnan, C., Eizirik, D. L., Mathieu, C., Cnop, M., Thorens, B. & Solimena, M.

Fostering improved human islet research: a European perspective.

Diabetologia 62, 1514–1516 (2019). doi:10.1007/s00125-019-4911-4

15.

Salem, V., Silva, L. D., Suba, K., Georgiadou, E., Gharavy, S. N. M., Akhtar, N., Martin-Alonso, A., Gaboriau, D. C. A., Rothery, S. M., Stylianides, T., Carrat, G., Pullen, T. J., Singh, S. P., Hodson, D. J., Leclerc, I., Shapiro, A. M. J., Marchetti, P., Briant, L. J. B., Distaso, W., Ninov, N. & Rutter, G. A.

Leader β-cells coordinate Ca 2+ dynamics across pancreatic islets in vivo.

Nature Metabolism 1, 615 (2019). doi:10.1038/s42255-019-0075-2

16.

Khamis, A., Canouil, M., Siddiq, A., Crouch, H., Falchi, M., Bulow, M. von, Ehehalt, F., Marselli, L., Distler, M., Richter, D., Weitz, J., Bokvist, K., Xenarios, I., Thorens, B., Schulte, A. M., Ibberson, M., Bonnefond, A., Marchetti, P., Solimena, M. & Froguel, P.

Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes.

Molecular Metabolism (2019). doi:10.1016/j.molmet.2019.03.004

17.

Toledo, P. L., Torkko, J. M., Müller, A., Wegbrod, C., Sönmez, A., Solimena, M. & Ermácora, M. R.

ICA512 RESP18 homology domain is a protein condensing factor and insulin fibrillation inhibitor.

bioRxiv 521351 (2019). doi:10.1101/521351

18.

Lytrivi, M., Igoillo-Esteve, M. & Cnop, M.

Inflammatory stress in islet β-cells: therapeutic implications for type 2 diabetes?.

Current Opinion in Pharmacology 43, 40–45 (2018). doi:10.1016/j.coph.2018.08.002

19.

Cosentino, C., Toivonen, S., Diaz Villamil, E., Atta, M., Ravanat, J.-L., Demine, S., Schiavo, A., Pachera, N., Deglasse, J.-P., Jonas, J.-C., Balboa, D., Otonkoski, T., Pearson, E. R., Marchetti, P., Eizirik, D. L., Cnop, M. & Igoillo-Esteve, M.

Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes.

Nucleic Acids Research 46, 10302–10318 (2018). doi:10.1093/nar/gky839

20.

Ahlqvist, E., Storm, P., Käräjämäki, A., Martinell, M., Dorkhan, M., Carlsson, A., Vikman, P., Prasad, R. B., Aly, D. M., Almgren, P., Wessman, Y., Shaat, N., Spégel, P., Mulder, H., Lindholm, E., Melander, O., Hansson, O., Malmqvist, U., Lernmark, Åke, Lahti, K., Forsén, T., Tuomi, T., Rosengren, A. H. & Groop, L.

Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables.

The Lancet Diabetes & Endocrinology 6, 361–369 (2018). doi:10.1016/S2213-8587(18)30051-2

21.

Rutter, G. A., Hodson, D. J., Chabosseau, P., Haythorne, E., Pullen, T. J. & Leclerc, I.

Local and regional control of calcium dynamics in the pancreatic islet.

Diabetes, Obesity and Metabolism 19, 30–41 (2017). doi:10.1111/dom.12990

22.

Canouil, M., Bouland, G. A., Bonnefond, A., Froguel, P., ’t Hart, L. M. & Slieker, R. C.

NACHO: an R package for quality control of NanoString nCounter data.

Bioinformatics doi:10.1093/bioinformatics/btz647

23.

Cosentino, C., Cnop, M. & Igoillo-Esteve, M.

The tRNA epitranscriptome and diabetes: emergence of tRNA hypomodifications as a cause of pancreatic β-cell failure.

Endocrinology doi:10.1210/en.2019-00098

24.

Leal, J., Morrow, L. M., Khurshid, W., Pagano, E. & Feenstra, T.

Decision models of prediabetes populations: A systematic review.

Diabetes, Obesity and Metabolism doi:10.1111/dom.13684

25.

Wagner, R., Jaghutriz, B. A., Gerst, F., Barroso Oquendo, M., Machann, J., Schick, F., Löffler, M., Nadalin, S., Fend, F., Königsrainer, A., Peter, A., Siegel-Axel, D., Ullrich, S., Häring, H.-U., Fritsche, A. & Heni, M.

Pancreatic steatosis associates with impaired insulin secretion in genetically predisposed individuals.

The Journal of Clinical Endocrinology & Metabolism doi:10.1210/clinem/dgaa435

1.

Mutie, P. M., Pomares-Millan, H., Atabaki-Pasdar, N., Jordan, N., Adams, R., Daly, N. L., Tajes, J. F., Giordano, G. N. & Franks, P. W.

An investigation of causal relationships between prediabetes and vascular complications.

Nature Communications 11, 4592 (2020). doi:10.1038/s41467-020-18386-9

2.

Amouyal, C., Castel, J., Guay, C., Lacombe, A., Denom, J., Migrenne-Li, S., Rouault, C., Marquet, F., Georgiadou, E., Stylianides, T., Luquet, S., Le Stunff, H., Scharfmann, R., Clément, K., Rutter, G. A., Taboureau, O., Magnan, C., Regazzi, R. & Andreelli, F.

A surrogate of Roux-en-Y gastric bypass (the enterogastro anastomosis surgery) regulates multiple beta-cell pathways during resolution of diabetes in ob/ob mice.

EBioMedicine 58, 102895 (2020). doi:10.1016/j.ebiom.2020.102895

3.

Gausserès, B., Liu, J., Foppen, E., Tourrel-Cuzin, C., Rodriguez Sanchez-Archidona, A., Delangre, E., Cruciani-Guglielmacci, C., Pons, S., Maskos, U., Thorens, B., Magnan, C., Movassat, J. & Maouche, K.

The Constitutive Lack of α7 Nicotinic Receptor Leads to Metabolic Disorders in Mouse.

Biomolecules 10, 1057 (2020). doi:10.3390/biom10071057

4.

Gharavy, S. N. M., Owen, B., Millership, S. J., Chabosseau, P., Pizza, G., Martinez-Sanchez, A., Tasoez, E., Georgiadou, E., Hu, M., Fine, N. H. F., Jacobson, D. A., Dickerson, M., Idevall-Hagren, O., Montoya, A., Kramer, H., Mehta, Z., Withers, D. J., Ninov, N., Gadue, P. J., Cardenas-Diaz, F. L., Cruciani-Guglielmacci, C., Magnan, C., Ibberson, M., Leclerc, I., Voz, M. & Rutter, G. A.

Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis.

bioRxiv 2020.05.18.099200 (2020). doi:10.1101/2020.05.18.099200

5.

Clough, T. J., Baxan, N., Coakley, E. J., Rivas, C., Zhao, L., Leclerc, I., Martinez-Sanchez, A., Rutter, G. A. & Long, N. J.

Synthesis and in vivo behaviour of an exendin-4-based MRI probe capable of β-cell-dependent contrast enhancement in the pancreas.

Dalton Transactions 49, 4732–4740 (2020). doi:10.1039/D0DT00332H

6.

Carrat, G. R., Haythorne, E., Tomas, A., Haataja, L., Mueller, A., Arvan, P., Piunti, A., Cheng, K., Huang, M., Pullen, T., Georgiadou, E., Stylianides, T., Amirruddin, N. S., Salem, V., Distaso, W., Cakebread, A., Heesom, K. J., Lewis, P. A., Hodson, D., Briant, L. J., Fung, A. C. H., Sessions, R. B., Alpy, F., Kong, A. P. S., Benke, P. I., Torta, F., Teo, A. K. K., Leclerc, I., Solimena, M., Wigley, D. B. & Rutter, G. A.

The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis.

bioRxiv 2020.03.25.007286 (2020). doi:10.1101/2020.03.25.007286

7.

Fang, Z., Chen, S., Pickford, P., Broichhagen, J., Hodson, D. J., Corrêa, I. R., Kumar, S., Görlitz, F., Dunsby, C., French, P., Rutter, G. A., Tan, T., Bloom, S. R., Tomas, A. & Jones, B.

The influence of peptide context on signalling and trafficking of glucagon-like peptide-1 receptor biased agonists.

bioRxiv 2020.02.24.961524 (2020). doi:10.1101/2020.02.24.961524

8.

Dominguez-Meijide, A., Vasili, E., König, A., Cima-Omori, M.-S., Leonov, A., Ryazanov, S., Zweckstetter, M., Griesinger, C. & Outeiro, T. F.

Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization.

bioRxiv 2020.01.27.921643 (2020). doi:10.1101/2020.01.27.921643

9.

Dumayne, C., Tarussio, D., Sanchez-Archidona, A. R., Picard, A., Basco, D., Berney, X. P., Ibberson, M. & Thorens, B.

Klf6 protects β-cells against insulin resistance-induced dedifferentiation.

Molecular Metabolism (2020). doi:10.1016/j.molmet.2020.02.001

10.

Georgiadou, E., Haythorne, E., Dickerson, M. T., Lopez-Noriega, L., Pullen, T. J., da Silva Xavier, G., Davis, S. P. X., Martinez-Sanchez, A., Semplici, F., Rizzuto, R., McGinty, J. A., French, P. M., Cane, M. C., Jacobson, D. A., Leclerc, I. & Rutter, G. A.

The pore-forming subunit MCU of the mitochondrial Ca2+ uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice.

Diabetologia 63, 1368–1381 (2020). doi:10.1007/s00125-020-05148-x

11.

Oshima, M., Pechberty, S., Bellini, L., Göpel, S. O., Campana, M., Rouch, C., Dairou, J., Cosentino, C., Fantuzzi, F., Toivonen, S., Marchetti, P., Magnan, C., Cnop, M., Le Stunff, H. & Scharfmann, R.

Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity.

Diabetologia 63, 395–409 (2020). doi:10.1007/s00125-019-05046-x

12.

Scharfmann, R., Staels, W. & Albagli, O.

The supply chain of human pancreatic β cell lines.

The Journal of Clinical Investigation 129, 3511–3520 (2019). doi:10.1172/JCI129484

13.

Thorens, B., Rodriguez, A., Cruciani-Guglielmacci, C., Wigger, L., Ibberson, M. & Magnan, C.

Use of preclinical models to identify markers of type 2 diabetes susceptibility and novel regulators of insulin secretion – A step towards precision medicine.

Molecular Metabolism 27, S147-S154 (2019). doi:10.1016/j.molmet.2019.06.008

14.

Marchetti, P., Schulte, A. M., Marselli, L., Schoniger, E., Bugliani, M., Kramer, W., Overbergh, L., Ullrich, S., Gloyn, A. L., Ibberson, M., Rutter, G., Froguel, P., Groop, L., McCarthy, M. I., Dotta, F., Scharfmann, R., Magnan, C., Eizirik, D. L., Mathieu, C., Cnop, M., Thorens, B. & Solimena, M.

Fostering improved human islet research: a European perspective.

Diabetologia 62, 1514–1516 (2019). doi:10.1007/s00125-019-4911-4

15.

Salem, V., Silva, L. D., Suba, K., Georgiadou, E., Gharavy, S. N. M., Akhtar, N., Martin-Alonso, A., Gaboriau, D. C. A., Rothery, S. M., Stylianides, T., Carrat, G., Pullen, T. J., Singh, S. P., Hodson, D. J., Leclerc, I., Shapiro, A. M. J., Marchetti, P., Briant, L. J. B., Distaso, W., Ninov, N. & Rutter, G. A.

Leader β-cells coordinate Ca 2+ dynamics across pancreatic islets in vivo.

Nature Metabolism 1, 615 (2019). doi:10.1038/s42255-019-0075-2

16.

Khamis, A., Canouil, M., Siddiq, A., Crouch, H., Falchi, M., Bulow, M. von, Ehehalt, F., Marselli, L., Distler, M., Richter, D., Weitz, J., Bokvist, K., Xenarios, I., Thorens, B., Schulte, A. M., Ibberson, M., Bonnefond, A., Marchetti, P., Solimena, M. & Froguel, P.

Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes.

Molecular Metabolism (2019). doi:10.1016/j.molmet.2019.03.004

17.

Toledo, P. L., Torkko, J. M., Müller, A., Wegbrod, C., Sönmez, A., Solimena, M. & Ermácora, M. R.

ICA512 RESP18 homology domain is a protein condensing factor and insulin fibrillation inhibitor.

bioRxiv 521351 (2019). doi:10.1101/521351

18.

Lytrivi, M., Igoillo-Esteve, M. & Cnop, M.

Inflammatory stress in islet β-cells: therapeutic implications for type 2 diabetes?.

Current Opinion in Pharmacology 43, 40–45 (2018). doi:10.1016/j.coph.2018.08.002

19.

Cosentino, C., Toivonen, S., Diaz Villamil, E., Atta, M., Ravanat, J.-L., Demine, S., Schiavo, A., Pachera, N., Deglasse, J.-P., Jonas, J.-C., Balboa, D., Otonkoski, T., Pearson, E. R., Marchetti, P., Eizirik, D. L., Cnop, M. & Igoillo-Esteve, M.

Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes.

Nucleic Acids Research 46, 10302–10318 (2018). doi:10.1093/nar/gky839

20.

Ahlqvist, E., Storm, P., Käräjämäki, A., Martinell, M., Dorkhan, M., Carlsson, A., Vikman, P., Prasad, R. B., Aly, D. M., Almgren, P., Wessman, Y., Shaat, N., Spégel, P., Mulder, H., Lindholm, E., Melander, O., Hansson, O., Malmqvist, U., Lernmark, Åke, Lahti, K., Forsén, T., Tuomi, T., Rosengren, A. H. & Groop, L.

Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables.

The Lancet Diabetes & Endocrinology 6, 361–369 (2018). doi:10.1016/S2213-8587(18)30051-2

21.

Rutter, G. A., Hodson, D. J., Chabosseau, P., Haythorne, E., Pullen, T. J. & Leclerc, I.

Local and regional control of calcium dynamics in the pancreatic islet.

Diabetes, Obesity and Metabolism 19, 30–41 (2017). doi:10.1111/dom.12990

22.

Canouil, M., Bouland, G. A., Bonnefond, A., Froguel, P., ’t Hart, L. M. & Slieker, R. C.

NACHO: an R package for quality control of NanoString nCounter data.

Bioinformatics doi:10.1093/bioinformatics/btz647

23.

Cosentino, C., Cnop, M. & Igoillo-Esteve, M.

The tRNA epitranscriptome and diabetes: emergence of tRNA hypomodifications as a cause of pancreatic β-cell failure.

Endocrinology doi:10.1210/en.2019-00098

24.

Leal, J., Morrow, L. M., Khurshid, W., Pagano, E. & Feenstra, T.

Decision models of prediabetes populations: A systematic review.

Diabetes, Obesity and Metabolism doi:10.1111/dom.13684

25.

Wagner, R., Jaghutriz, B. A., Gerst, F., Barroso Oquendo, M., Machann, J., Schick, F., Löffler, M., Nadalin, S., Fend, F., Königsrainer, A., Peter, A., Siegel-Axel, D., Ullrich, S., Häring, H.-U., Fritsche, A. & Heni, M.

Pancreatic steatosis associates with impaired insulin secretion in genetically predisposed individuals.

The Journal of Clinical Endocrinology & Metabolism doi:10.1210/clinem/dgaa435

1.

Mutie, P. M., Pomares-Millan, H., Atabaki-Pasdar, N., Jordan, N., Adams, R., Daly, N. L., Tajes, J. F., Giordano, G. N. & Franks, P. W.

An investigation of causal relationships between prediabetes and vascular complications.

Nature Communications 11, 4592 (2020). doi:10.1038/s41467-020-18386-9

2.

Amouyal, C., Castel, J., Guay, C., Lacombe, A., Denom, J., Migrenne-Li, S., Rouault, C., Marquet, F., Georgiadou, E., Stylianides, T., Luquet, S., Le Stunff, H., Scharfmann, R., Clément, K., Rutter, G. A., Taboureau, O., Magnan, C., Regazzi, R. & Andreelli, F.

A surrogate of Roux-en-Y gastric bypass (the enterogastro anastomosis surgery) regulates multiple beta-cell pathways during resolution of diabetes in ob/ob mice.

EBioMedicine 58, 102895 (2020). doi:10.1016/j.ebiom.2020.102895

3.

Gausserès, B., Liu, J., Foppen, E., Tourrel-Cuzin, C., Rodriguez Sanchez-Archidona, A., Delangre, E., Cruciani-Guglielmacci, C., Pons, S., Maskos, U., Thorens, B., Magnan, C., Movassat, J. & Maouche, K.

The Constitutive Lack of α7 Nicotinic Receptor Leads to Metabolic Disorders in Mouse.

Biomolecules 10, 1057 (2020). doi:10.3390/biom10071057

4.

Gharavy, S. N. M., Owen, B., Millership, S. J., Chabosseau, P., Pizza, G., Martinez-Sanchez, A., Tasoez, E., Georgiadou, E., Hu, M., Fine, N. H. F., Jacobson, D. A., Dickerson, M., Idevall-Hagren, O., Montoya, A., Kramer, H., Mehta, Z., Withers, D. J., Ninov, N., Gadue, P. J., Cardenas-Diaz, F. L., Cruciani-Guglielmacci, C., Magnan, C., Ibberson, M., Leclerc, I., Voz, M. & Rutter, G. A.

Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis.

bioRxiv 2020.05.18.099200 (2020). doi:10.1101/2020.05.18.099200

5.

Clough, T. J., Baxan, N., Coakley, E. J., Rivas, C., Zhao, L., Leclerc, I., Martinez-Sanchez, A., Rutter, G. A. & Long, N. J.

Synthesis and in vivo behaviour of an exendin-4-based MRI probe capable of β-cell-dependent contrast enhancement in the pancreas.

Dalton Transactions 49, 4732–4740 (2020). doi:10.1039/D0DT00332H

6.

Carrat, G. R., Haythorne, E., Tomas, A., Haataja, L., Mueller, A., Arvan, P., Piunti, A., Cheng, K., Huang, M., Pullen, T., Georgiadou, E., Stylianides, T., Amirruddin, N. S., Salem, V., Distaso, W., Cakebread, A., Heesom, K. J., Lewis, P. A., Hodson, D., Briant, L. J., Fung, A. C. H., Sessions, R. B., Alpy, F., Kong, A. P. S., Benke, P. I., Torta, F., Teo, A. K. K., Leclerc, I., Solimena, M., Wigley, D. B. & Rutter, G. A.

The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis.

bioRxiv 2020.03.25.007286 (2020). doi:10.1101/2020.03.25.007286

7.

Fang, Z., Chen, S., Pickford, P., Broichhagen, J., Hodson, D. J., Corrêa, I. R., Kumar, S., Görlitz, F., Dunsby, C., French, P., Rutter, G. A., Tan, T., Bloom, S. R., Tomas, A. & Jones, B.

The influence of peptide context on signalling and trafficking of glucagon-like peptide-1 receptor biased agonists.

bioRxiv 2020.02.24.961524 (2020). doi:10.1101/2020.02.24.961524

8.

Dominguez-Meijide, A., Vasili, E., König, A., Cima-Omori, M.-S., Leonov, A., Ryazanov, S., Zweckstetter, M., Griesinger, C. & Outeiro, T. F.

Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization.

bioRxiv 2020.01.27.921643 (2020). doi:10.1101/2020.01.27.921643

9.

Dumayne, C., Tarussio, D., Sanchez-Archidona, A. R., Picard, A., Basco, D., Berney, X. P., Ibberson, M. & Thorens, B.

Klf6 protects β-cells against insulin resistance-induced dedifferentiation.

Molecular Metabolism (2020). doi:10.1016/j.molmet.2020.02.001

10.

Georgiadou, E., Haythorne, E., Dickerson, M. T., Lopez-Noriega, L., Pullen, T. J., da Silva Xavier, G., Davis, S. P. X., Martinez-Sanchez, A., Semplici, F., Rizzuto, R., McGinty, J. A., French, P. M., Cane, M. C., Jacobson, D. A., Leclerc, I. & Rutter, G. A.

The pore-forming subunit MCU of the mitochondrial Ca2+ uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice.

Diabetologia 63, 1368–1381 (2020). doi:10.1007/s00125-020-05148-x

11.

Oshima, M., Pechberty, S., Bellini, L., Göpel, S. O., Campana, M., Rouch, C., Dairou, J., Cosentino, C., Fantuzzi, F., Toivonen, S., Marchetti, P., Magnan, C., Cnop, M., Le Stunff, H. & Scharfmann, R.

Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity.

Diabetologia 63, 395–409 (2020). doi:10.1007/s00125-019-05046-x

12.

Scharfmann, R., Staels, W. & Albagli, O.

The supply chain of human pancreatic β cell lines.

The Journal of Clinical Investigation 129, 3511–3520 (2019). doi:10.1172/JCI129484

13.

Thorens, B., Rodriguez, A., Cruciani-Guglielmacci, C., Wigger, L., Ibberson, M. & Magnan, C.

Use of preclinical models to identify markers of type 2 diabetes susceptibility and novel regulators of insulin secretion – A step towards precision medicine.

Molecular Metabolism 27, S147-S154 (2019). doi:10.1016/j.molmet.2019.06.008

14.

Marchetti, P., Schulte, A. M., Marselli, L., Schoniger, E., Bugliani, M., Kramer, W., Overbergh, L., Ullrich, S., Gloyn, A. L., Ibberson, M., Rutter, G., Froguel, P., Groop, L., McCarthy, M. I., Dotta, F., Scharfmann, R., Magnan, C., Eizirik, D. L., Mathieu, C., Cnop, M., Thorens, B. & Solimena, M.

Fostering improved human islet research: a European perspective.

Diabetologia 62, 1514–1516 (2019). doi:10.1007/s00125-019-4911-4

15.

Salem, V., Silva, L. D., Suba, K., Georgiadou, E., Gharavy, S. N. M., Akhtar, N., Martin-Alonso, A., Gaboriau, D. C. A., Rothery, S. M., Stylianides, T., Carrat, G., Pullen, T. J., Singh, S. P., Hodson, D. J., Leclerc, I., Shapiro, A. M. J., Marchetti, P., Briant, L. J. B., Distaso, W., Ninov, N. & Rutter, G. A.

Leader β-cells coordinate Ca 2+ dynamics across pancreatic islets in vivo.

Nature Metabolism 1, 615 (2019). doi:10.1038/s42255-019-0075-2

16.

Khamis, A., Canouil, M., Siddiq, A., Crouch, H., Falchi, M., Bulow, M. von, Ehehalt, F., Marselli, L., Distler, M., Richter, D., Weitz, J., Bokvist, K., Xenarios, I., Thorens, B., Schulte, A. M., Ibberson, M., Bonnefond, A., Marchetti, P., Solimena, M. & Froguel, P.

Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes.

Molecular Metabolism (2019). doi:10.1016/j.molmet.2019.03.004

17.

Toledo, P. L., Torkko, J. M., Müller, A., Wegbrod, C., Sönmez, A., Solimena, M. & Ermácora, M. R.

ICA512 RESP18 homology domain is a protein condensing factor and insulin fibrillation inhibitor.

bioRxiv 521351 (2019). doi:10.1101/521351

18.

Lytrivi, M., Igoillo-Esteve, M. & Cnop, M.

Inflammatory stress in islet β-cells: therapeutic implications for type 2 diabetes?.

Current Opinion in Pharmacology 43, 40–45 (2018). doi:10.1016/j.coph.2018.08.002

19.

Cosentino, C., Toivonen, S., Diaz Villamil, E., Atta, M., Ravanat, J.-L., Demine, S., Schiavo, A., Pachera, N., Deglasse, J.-P., Jonas, J.-C., Balboa, D., Otonkoski, T., Pearson, E. R., Marchetti, P., Eizirik, D. L., Cnop, M. & Igoillo-Esteve, M.

Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes.

Nucleic Acids Research 46, 10302–10318 (2018). doi:10.1093/nar/gky839

20.

Ahlqvist, E., Storm, P., Käräjämäki, A., Martinell, M., Dorkhan, M., Carlsson, A., Vikman, P., Prasad, R. B., Aly, D. M., Almgren, P., Wessman, Y., Shaat, N., Spégel, P., Mulder, H., Lindholm, E., Melander, O., Hansson, O., Malmqvist, U., Lernmark, Åke, Lahti, K., Forsén, T., Tuomi, T., Rosengren, A. H. & Groop, L.

Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables.

The Lancet Diabetes & Endocrinology 6, 361–369 (2018). doi:10.1016/S2213-8587(18)30051-2

21.

Rutter, G. A., Hodson, D. J., Chabosseau, P., Haythorne, E., Pullen, T. J. & Leclerc, I.

Local and regional control of calcium dynamics in the pancreatic islet.

Diabetes, Obesity and Metabolism 19, 30–41 (2017). doi:10.1111/dom.12990

22.

Canouil, M., Bouland, G. A., Bonnefond, A., Froguel, P., ’t Hart, L. M. & Slieker, R. C.

NACHO: an R package for quality control of NanoString nCounter data.

Bioinformatics doi:10.1093/bioinformatics/btz647

23.

Cosentino, C., Cnop, M. & Igoillo-Esteve, M.

The tRNA epitranscriptome and diabetes: emergence of tRNA hypomodifications as a cause of pancreatic β-cell failure.

Endocrinology doi:10.1210/en.2019-00098

24.

Leal, J., Morrow, L. M., Khurshid, W., Pagano, E. & Feenstra, T.

Decision models of prediabetes populations: A systematic review.

Diabetes, Obesity and Metabolism doi:10.1111/dom.13684

25.

Wagner, R., Jaghutriz, B. A., Gerst, F., Barroso Oquendo, M., Machann, J., Schick, F., Löffler, M., Nadalin, S., Fend, F., Königsrainer, A., Peter, A., Siegel-Axel, D., Ullrich, S., Häring, H.-U., Fritsche, A. & Heni, M.

Pancreatic steatosis associates with impaired insulin secretion in genetically predisposed individuals.

The Journal of Clinical Endocrinology & Metabolism doi:10.1210/clinem/dgaa435

1.

Mutie, P. M., Pomares-Millan, H., Atabaki-Pasdar, N., Jordan, N., Adams, R., Daly, N. L., Tajes, J. F., Giordano, G. N. & Franks, P. W.

An investigation of causal relationships between prediabetes and vascular complications.

Nature Communications 11, 4592 (2020). doi:10.1038/s41467-020-18386-9

2.

Amouyal, C., Castel, J., Guay, C., Lacombe, A., Denom, J., Migrenne-Li, S., Rouault, C., Marquet, F., Georgiadou, E., Stylianides, T., Luquet, S., Le Stunff, H., Scharfmann, R., Clément, K., Rutter, G. A., Taboureau, O., Magnan, C., Regazzi, R. & Andreelli, F.

A surrogate of Roux-en-Y gastric bypass (the enterogastro anastomosis surgery) regulates multiple beta-cell pathways during resolution of diabetes in ob/ob mice.

EBioMedicine 58, 102895 (2020). doi:10.1016/j.ebiom.2020.102895

3.

Gausserès, B., Liu, J., Foppen, E., Tourrel-Cuzin, C., Rodriguez Sanchez-Archidona, A., Delangre, E., Cruciani-Guglielmacci, C., Pons, S., Maskos, U., Thorens, B., Magnan, C., Movassat, J. & Maouche, K.

The Constitutive Lack of α7 Nicotinic Receptor Leads to Metabolic Disorders in Mouse.

Biomolecules 10, 1057 (2020). doi:10.3390/biom10071057

4.

Gharavy, S. N. M., Owen, B., Millership, S. J., Chabosseau, P., Pizza, G., Martinez-Sanchez, A., Tasoez, E., Georgiadou, E., Hu, M., Fine, N. H. F., Jacobson, D. A., Dickerson, M., Idevall-Hagren, O., Montoya, A., Kramer, H., Mehta, Z., Withers, D. J., Ninov, N., Gadue, P. J., Cardenas-Diaz, F. L., Cruciani-Guglielmacci, C., Magnan, C., Ibberson, M., Leclerc, I., Voz, M. & Rutter, G. A.

Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis.

bioRxiv 2020.05.18.099200 (2020). doi:10.1101/2020.05.18.099200

5.

Clough, T. J., Baxan, N., Coakley, E. J., Rivas, C., Zhao, L., Leclerc, I., Martinez-Sanchez, A., Rutter, G. A. & Long, N. J.

Synthesis and in vivo behaviour of an exendin-4-based MRI probe capable of β-cell-dependent contrast enhancement in the pancreas.

Dalton Transactions 49, 4732–4740 (2020). doi:10.1039/D0DT00332H

6.

Carrat, G. R., Haythorne, E., Tomas, A., Haataja, L., Mueller, A., Arvan, P., Piunti, A., Cheng, K., Huang, M., Pullen, T., Georgiadou, E., Stylianides, T., Amirruddin, N. S., Salem, V., Distaso, W., Cakebread, A., Heesom, K. J., Lewis, P. A., Hodson, D., Briant, L. J., Fung, A. C. H., Sessions, R. B., Alpy, F., Kong, A. P. S., Benke, P. I., Torta, F., Teo, A. K. K., Leclerc, I., Solimena, M., Wigley, D. B. & Rutter, G. A.

The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis.

bioRxiv 2020.03.25.007286 (2020). doi:10.1101/2020.03.25.007286

7.

Fang, Z., Chen, S., Pickford, P., Broichhagen, J., Hodson, D. J., Corrêa, I. R., Kumar, S., Görlitz, F., Dunsby, C., French, P., Rutter, G. A., Tan, T., Bloom, S. R., Tomas, A. & Jones, B.

The influence of peptide context on signalling and trafficking of glucagon-like peptide-1 receptor biased agonists.

bioRxiv 2020.02.24.961524 (2020). doi:10.1101/2020.02.24.961524

8.

Dominguez-Meijide, A., Vasili, E., König, A., Cima-Omori, M.-S., Leonov, A., Ryazanov, S., Zweckstetter, M., Griesinger, C. & Outeiro, T. F.

Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization.

bioRxiv 2020.01.27.921643 (2020). doi:10.1101/2020.01.27.921643

9.

Dumayne, C., Tarussio, D., Sanchez-Archidona, A. R., Picard, A., Basco, D., Berney, X. P., Ibberson, M. & Thorens, B.

Klf6 protects β-cells against insulin resistance-induced dedifferentiation.

Molecular Metabolism (2020). doi:10.1016/j.molmet.2020.02.001

10.

Georgiadou, E., Haythorne, E., Dickerson, M. T., Lopez-Noriega, L., Pullen, T. J., da Silva Xavier, G., Davis, S. P. X., Martinez-Sanchez, A., Semplici, F., Rizzuto, R., McGinty, J. A., French, P. M., Cane, M. C., Jacobson, D. A., Leclerc, I. & Rutter, G. A.

The pore-forming subunit MCU of the mitochondrial Ca2+ uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice.

Diabetologia 63, 1368–1381 (2020). doi:10.1007/s00125-020-05148-x

11.

Oshima, M., Pechberty, S., Bellini, L., Göpel, S. O., Campana, M., Rouch, C., Dairou, J., Cosentino, C., Fantuzzi, F., Toivonen, S., Marchetti, P., Magnan, C., Cnop, M., Le Stunff, H. & Scharfmann, R.

Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity.

Diabetologia 63, 395–409 (2020). doi:10.1007/s00125-019-05046-x

12.

Scharfmann, R., Staels, W. & Albagli, O.

The supply chain of human pancreatic β cell lines.

The Journal of Clinical Investigation 129, 3511–3520 (2019). doi:10.1172/JCI129484

13.

Thorens, B., Rodriguez, A., Cruciani-Guglielmacci, C., Wigger, L., Ibberson, M. & Magnan, C.

Use of preclinical models to identify markers of type 2 diabetes susceptibility and novel regulators of insulin secretion – A step towards precision medicine.

Molecular Metabolism 27, S147-S154 (2019). doi:10.1016/j.molmet.2019.06.008

14.

Marchetti, P., Schulte, A. M., Marselli, L., Schoniger, E., Bugliani, M., Kramer, W., Overbergh, L., Ullrich, S., Gloyn, A. L., Ibberson, M., Rutter, G., Froguel, P., Groop, L., McCarthy, M. I., Dotta, F., Scharfmann, R., Magnan, C., Eizirik, D. L., Mathieu, C., Cnop, M., Thorens, B. & Solimena, M.

Fostering improved human islet research: a European perspective.

Diabetologia 62, 1514–1516 (2019). doi:10.1007/s00125-019-4911-4

15.

Salem, V., Silva, L. D., Suba, K., Georgiadou, E., Gharavy, S. N. M., Akhtar, N., Martin-Alonso, A., Gaboriau, D. C. A., Rothery, S. M., Stylianides, T., Carrat, G., Pullen, T. J., Singh, S. P., Hodson, D. J., Leclerc, I., Shapiro, A. M. J., Marchetti, P., Briant, L. J. B., Distaso, W., Ninov, N. & Rutter, G. A.

Leader β-cells coordinate Ca 2+ dynamics across pancreatic islets in vivo.

Nature Metabolism 1, 615 (2019). doi:10.1038/s42255-019-0075-2

16.

Khamis, A., Canouil, M., Siddiq, A., Crouch, H., Falchi, M., Bulow, M. von, Ehehalt, F., Marselli, L., Distler, M., Richter, D., Weitz, J., Bokvist, K., Xenarios, I., Thorens, B., Schulte, A. M., Ibberson, M., Bonnefond, A., Marchetti, P., Solimena, M. & Froguel, P.

Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes.

Molecular Metabolism (2019). doi:10.1016/j.molmet.2019.03.004

17.

Toledo, P. L., Torkko, J. M., Müller, A., Wegbrod, C., Sönmez, A., Solimena, M. & Ermácora, M. R.

ICA512 RESP18 homology domain is a protein condensing factor and insulin fibrillation inhibitor.

bioRxiv 521351 (2019). doi:10.1101/521351

18.

Lytrivi, M., Igoillo-Esteve, M. & Cnop, M.

Inflammatory stress in islet β-cells: therapeutic implications for type 2 diabetes?.

Current Opinion in Pharmacology 43, 40–45 (2018). doi:10.1016/j.coph.2018.08.002

19.

Cosentino, C., Toivonen, S., Diaz Villamil, E., Atta, M., Ravanat, J.-L., Demine, S., Schiavo, A., Pachera, N., Deglasse, J.-P., Jonas, J.-C., Balboa, D., Otonkoski, T., Pearson, E. R., Marchetti, P., Eizirik, D. L., Cnop, M. & Igoillo-Esteve, M.

Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes.

Nucleic Acids Research 46, 10302–10318 (2018). doi:10.1093/nar/gky839

20.

Ahlqvist, E., Storm, P., Käräjämäki, A., Martinell, M., Dorkhan, M., Carlsson, A., Vikman, P., Prasad, R. B., Aly, D. M., Almgren, P., Wessman, Y., Shaat, N., Spégel, P., Mulder, H., Lindholm, E., Melander, O., Hansson, O., Malmqvist, U., Lernmark, Åke, Lahti, K., Forsén, T., Tuomi, T., Rosengren, A. H. & Groop, L.

Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables.

The Lancet Diabetes & Endocrinology 6, 361–369 (2018). doi:10.1016/S2213-8587(18)30051-2

21.

Rutter, G. A., Hodson, D. J., Chabosseau, P., Haythorne, E., Pullen, T. J. & Leclerc, I.

Local and regional control of calcium dynamics in the pancreatic islet.

Diabetes, Obesity and Metabolism 19, 30–41 (2017). doi:10.1111/dom.12990

22.

Canouil, M., Bouland, G. A., Bonnefond, A., Froguel, P., ’t Hart, L. M. & Slieker, R. C.

NACHO: an R package for quality control of NanoString nCounter data.

Bioinformatics doi:10.1093/bioinformatics/btz647

23.

Cosentino, C., Cnop, M. & Igoillo-Esteve, M.

The tRNA epitranscriptome and diabetes: emergence of tRNA hypomodifications as a cause of pancreatic β-cell failure.

Endocrinology doi:10.1210/en.2019-00098

24.

Leal, J., Morrow, L. M., Khurshid, W., Pagano, E. & Feenstra, T.

Decision models of prediabetes populations: A systematic review.

Diabetes, Obesity and Metabolism doi:10.1111/dom.13684

25.

Wagner, R., Jaghutriz, B. A., Gerst, F., Barroso Oquendo, M., Machann, J., Schick, F., Löffler, M., Nadalin, S., Fend, F., Königsrainer, A., Peter, A., Siegel-Axel, D., Ullrich, S., Häring, H.-U., Fritsche, A. & Heni, M.

Pancreatic steatosis associates with impaired insulin secretion in genetically predisposed individuals.

The Journal of Clinical Endocrinology & Metabolism doi:10.1210/clinem/dgaa435

Latest news

RHAPSODY 5th Consortium Meeting

Today took place the 5th RHAPSODY Consortium Meeting. An unusual online format that didn't affect the quality of the scientific
» Read more

RHAPSODY talks at EASD on 24 and 25 September

You are interested in #insulin biosynthesis? Enter Vienna Hall on 24 Sep and 25 Sep to listen to six RHAPSODY partners talk on the
» Read more

Come talk with RHAPSODY scientists @ EASD2020 posters session

On Wednesday 23 and Thursday 24 of September, RHAPSODY advancement will be presented @ EASD2020 through six posters
» Read more

Stacks Image p6767_n47

Stacks Image p6767_n398

Stacks Image p6767_n51

Stacks Image p6767_n349

This project receives funding from the Innovative Medicines Initiative 2 Joint Undertaking (www.imi.europa.eu) under grant agreement No 115881. This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation programme and EFPIA.

This work is supported by the Swiss State Secretariat for Education‚ Research and Innovation (SERI) under contract number 16.0097-2.

The opinions expressed and arguments employed herein do not necessarily reflect the official views of these funding bodies.

About Horizon 2020

Follow us on Twitter

Stacks Image p6767_n43

© 2019 RHAPSODY Project
Created by SCIPROM