Public Events

RHAPSODY organises public conference to inform a broad audience about its findings.

Summary for publication

RHAPSODY produces annual publishable reports which describe the project achievements. They are public and and the latest can be downloaded by clicking on the link below.

Videos

The findings of a seminal RHAPSODY publication have been summarised in a short video presentation by Lund University.

Project Flyer

The RHAPSODY project flyer describes the project at a glance. It is mainly intended as a printed product but its electronic version is available for download.

Scientific publications

Publications in peer-reviewed journals, conference proceedings, book chapters and books.
1.
The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis.
bioRxiv 2020.03.25.007286 (2020). doi:10.1101/2020.03.25.007286
2.
The influence of peptide context on signalling and trafficking of glucagon-like peptide-1 receptor biased agonists.
bioRxiv 2020.02.24.961524 (2020). doi:10.1101/2020.02.24.961524
3.
Klf6 protects β-cells against insulin resistance-induced dedifferentiation.
Molecular Metabolism (2020). doi:10.1016/j.molmet.2020.02.001
4.
Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity.
Diabetologia 63, 395-409 (2020). doi:10.1007/s00125-019-05046-x
5.
The supply chain of human pancreatic β cell lines.
The Journal of Clinical Investigation 129, 3511-3520 (2019). doi:10.1172/JCI129484
6.
Leader β-cells coordinate Ca 2+ dynamics across pancreatic islets in vivo.
Nature Metabolism 1, 615 (2019). doi:10.1038/s42255-019-0075-2
7.
Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes.
Molecular Metabolism (2019). doi:10.1016/j.molmet.2019.03.004
8.
ICA512 RESP18 homology domain is a protein condensing factor and insulin fibrillation inhibitor.
bioRxiv 521351 (2019). doi:10.1101/521351
9.
The Expression of Aldolase B in Islets Is Negatively Associated With Insulin Secretion in Humans.
The Journal of Clinical Endocrinology & Metabolism 103, 4373-4383 (2018). doi:10.1210/jc.2018-00791
10.
Inflammatory stress in islet β-cells: therapeutic implications for type 2 diabetes?.
Current Opinion in Pharmacology 43, 40-45 (2018). doi:10.1016/j.coph.2018.08.002
11.
Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes.
Nucleic Acids Research 46, 10302-10318 (2018). doi:10.1093/nar/gky839
12.
Prediction of Glucose Tolerance without an Oral Glucose Tolerance Test.
Frontiers in Endocrinology 9, (2018). doi:10.3389/fendo.2018.00082
13.
Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables.
The Lancet Diabetes & Endocrinology 6, 361-369 (2018). doi:10.1016/S2213-8587(18)30051-2
14.
Modeling human pancreatic beta cell dedifferentiation.
Molecular Metabolism 10, 74-86 (2018). doi:10.1016/j.molmet.2018.02.002
15.
MondoA Is an Essential Glucose-Responsive Transcription Factor in Human Pancreatic β-Cells.
Diabetes 67, 461-472 (2018). doi:10.2337/db17-0595
16.
HbA1c is associated with altered expression in blood of cell cycle- and immune response-related genes.
Diabetologia 61, 138-146 (2018). doi:10.1007/s00125-017-4467-0
17.
Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells.
Molecular Metabolism 6, 1024-1039 (2017). doi:10.1016/j.molmet.2017.06.001
18.
Lifestyle and precision diabetes medicine: will genomics help optimise the prediction, prevention and treatment of type 2 diabetes through lifestyle therapy?.
Diabetologia 60, 784-792 (2017). doi:10.1007/s00125-017-4207-5
19.
Local and regional control of calcium dynamics in the pancreatic islet.
Diabetes, Obesity and Metabolism 19, 30-41 (2017). doi:10.1111/dom.12990
20.
21.
22.
23.
NACHO: an R package for quality control of NanoString nCounter data.
Bioinformatics doi:10.1093/bioinformatics/btz647
24.
The tRNA epitranscriptome and diabetes: emergence of tRNA hypomodifications as a cause of pancreatic β-cell failure.
Endocrinology doi:10.1210/en.2019-00098
25.
Decision models of prediabetes populations: A systematic review.
Diabetes, Obesity and Metabolism doi:10.1111/dom.13684

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This project receives funding from the Innovative Medicines Initiative 2 Joint Undertaking (www.imi.europa.eu) under grant agreement No 115881. This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation programme and EFPIA.

This work is supported by the Swiss State Secretariat for Education‚ Research and Innovation (SERI) under contract number 16.0097-2.

The opinions expressed and arguments employed herein do not necessarily reflect the official views of these funding bodies.