Public Events

RHAPSODY organises public conference to inform a broad audience about its findings.

Summary for publication

RHAPSODY produces annual publishable reports which describe the project achievements. They are public and and the latest can be downloaded by clicking on the link below.

Videos

The findings of a seminal RHAPSODY publication have been summarised in a short video presentation by Lund University.
“Personalizing” medicine has gained significant momentum in recent years. Watch this short RHAPSODY teaser by Andreas Festa, certified internal medicine specialist, general practitioner and consultant for Eli Lilly.

Project Flyer

The RHAPSODY project flyer describes the project at a glance. It is mainly intended as a printed product but its electronic version is available for download.

Scientific publications

Publications in peer-reviewed journals, conference proceedings, book chapters and books.
1.
An investigation of causal relationships between prediabetes and vascular complications.
Nature Communications 11, 4592 (2020). doi:10.1038/s41467-020-18386-9
2.
A surrogate of Roux-en-Y gastric bypass (the enterogastro anastomosis surgery) regulates multiple beta-cell pathways during resolution of diabetes in ob/ob mice.
EBioMedicine 58, 102895 (2020). doi:10.1016/j.ebiom.2020.102895
3.
The Constitutive Lack of α7 Nicotinic Receptor Leads to Metabolic Disorders in Mouse.
Biomolecules 10, 1057 (2020). doi:10.3390/biom10071057
4.
Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis.
bioRxiv 2020.05.18.099200 (2020). doi:10.1101/2020.05.18.099200
5.
Synthesis and in vivo behaviour of an exendin-4-based MRI probe capable of β-cell-dependent contrast enhancement in the pancreas.
Dalton Transactions 49, 4732–4740 (2020). doi:10.1039/D0DT00332H
6.
The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis.
bioRxiv 2020.03.25.007286 (2020). doi:10.1101/2020.03.25.007286
7.
The influence of peptide context on signalling and trafficking of glucagon-like peptide-1 receptor biased agonists.
bioRxiv 2020.02.24.961524 (2020). doi:10.1101/2020.02.24.961524
8.
Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization.
bioRxiv 2020.01.27.921643 (2020). doi:10.1101/2020.01.27.921643
9.
Klf6 protects β-cells against insulin resistance-induced dedifferentiation.
Molecular Metabolism (2020). doi:10.1016/j.molmet.2020.02.001
10.
The pore-forming subunit MCU of the mitochondrial Ca2+ uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice.
Diabetologia 63, 1368–1381 (2020). doi:10.1007/s00125-020-05148-x
11.
Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity.
Diabetologia 63, 395–409 (2020). doi:10.1007/s00125-019-05046-x
12.
The supply chain of human pancreatic β cell lines.
The Journal of Clinical Investigation 129, 3511–3520 (2019). doi:10.1172/JCI129484
13.
Use of preclinical models to identify markers of type 2 diabetes susceptibility and novel regulators of insulin secretion – A step towards precision medicine.
Molecular Metabolism 27, S147-S154 (2019). doi:10.1016/j.molmet.2019.06.008
14.
Fostering improved human islet research: a European perspective.
Diabetologia 62, 1514–1516 (2019). doi:10.1007/s00125-019-4911-4
15.
Leader β-cells coordinate Ca 2+ dynamics across pancreatic islets in vivo.
Nature Metabolism 1, 615 (2019). doi:10.1038/s42255-019-0075-2
16.
Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes.
Molecular Metabolism (2019). doi:10.1016/j.molmet.2019.03.004
17.
ICA512 RESP18 homology domain is a protein condensing factor and insulin fibrillation inhibitor.
bioRxiv 521351 (2019). doi:10.1101/521351
18.
Inflammatory stress in islet β-cells: therapeutic implications for type 2 diabetes?.
Current Opinion in Pharmacology 43, 40–45 (2018). doi:10.1016/j.coph.2018.08.002
19.
Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes.
Nucleic Acids Research 46, 10302–10318 (2018). doi:10.1093/nar/gky839
20.
Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables.
The Lancet Diabetes & Endocrinology 6, 361–369 (2018). doi:10.1016/S2213-8587(18)30051-2
21.
Local and regional control of calcium dynamics in the pancreatic islet.
Diabetes, Obesity and Metabolism 19, 30–41 (2017). doi:10.1111/dom.12990
22.
NACHO: an R package for quality control of NanoString nCounter data.
Bioinformatics doi:10.1093/bioinformatics/btz647
23.
The tRNA epitranscriptome and diabetes: emergence of tRNA hypomodifications as a cause of pancreatic β-cell failure.
Endocrinology doi:10.1210/en.2019-00098
24.
Decision models of prediabetes populations: A systematic review.
Diabetes, Obesity and Metabolism doi:10.1111/dom.13684
25.
Pancreatic steatosis associates with impaired insulin secretion in genetically predisposed individuals.
The Journal of Clinical Endocrinology & Metabolism doi:10.1210/clinem/dgaa435

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This project receives funding from the Innovative Medicines Initiative 2 Joint Undertaking (www.imi.europa.eu) under grant agreement No 115881. This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation programme and EFPIA.

This work is supported by the Swiss State Secretariat for Education‚ Research and Innovation (SERI) under contract number 16.0097-2.

The opinions expressed and arguments employed herein do not necessarily reflect the official views of these funding bodies.